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dc.contributor.authorGunn-Moore, Francis James
dc.contributor.authorTilston-Lunel, Andrew Martin
dc.contributor.authorReynolds, Paul Andrew
dc.date.accessioned2016-07-21T15:30:05Z
dc.date.available2016-07-21T15:30:05Z
dc.date.issued2016-07-18
dc.identifier.citationGunn-Moore , F J , Tilston-Lunel , A M & Reynolds , P A 2016 , ' Willing to be involved in cancer ' , Genes , vol. 7 , no. 7 , 37 . https://doi.org/10.3390/genes7070037en
dc.identifier.issn2073-4425
dc.identifier.otherPURE: 244239701
dc.identifier.otherPURE UUID: 92f8c56f-b082-4f9e-ad60-af113314a6a7
dc.identifier.otherScopus: 84979240016
dc.identifier.otherWOS: 000381493100008
dc.identifier.urihttp://hdl.handle.net/10023/9189
dc.descriptionF.J.G-M., A.M.T-L. and P.A.R. were funded by the Anonymous Trust, University of St Andrews.en
dc.description.abstractGenome sequencing is now a common procedure, but prior to this, screening experiments using protein baits was one of the routinely used methods that, occasionally, allowed the identification of new gene products. One such experiment uncovered the gene product called willin/human Expanded/FRMD6. Initial characterization studies found that willin bound phospholipids and was strongly co-localised with actin. However, subsequently, willin was found to be the closest human sequence homologue of the Drosophila protein Expanded (Ex), sharing 60% homology with the Ex FERM domain. This in turn suggested, and then was proven that willin could activate the Hippo signalling pathway. This review describes the increasing body of knowledge about the actions of willin in a number of cellular functions related to cancer. However, like many gene products involved in aspects of cell signalling, a convincing direct role for willin in cancer remains tantalising elusive, at present.
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofGenesen
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectWillinen
dc.subjectFRMD6en
dc.subjectFERM proteinsen
dc.subjectCanceren
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQH426 Geneticsen
dc.subjectQH301 Biologyen
dc.subject.lccRC0254en
dc.subject.lccQH426en
dc.subject.lccQH301en
dc.titleWilling to be involved in canceren
dc.typeJournal itemen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.identifier.doihttps://doi.org/10.3390/genes7070037
dc.description.statusPeer revieweden


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