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dc.contributor.authorPuxty, Richard J.
dc.contributor.authorMillard, Andrew D.
dc.contributor.authorEvans, David John
dc.contributor.authorScanlan, David J.
dc.identifier.citationPuxty , RJ , Millard , AD , Evans , D J & Scanlan , DJ 2016 , ' Viruses inhibit CO 2 fixation in the most abundant phototrophs on Earth ' , Current Biology , vol. 26 , no. 12 , pp. 1585-1589 .
dc.identifier.otherRIS: urn:7BACED905C0661C5DB983525CA85141A
dc.identifier.otherORCID: /0000-0002-1315-4258/work/104252551
dc.descriptionR.J.P. was the recipient of a NERC studentship and Warwick University IAS fellowship. This work was supported in part by NERC grant NE/J02273X/1 and Leverhulme Trust grant RPG-2014-354 to A.D.M., D.J.E., and D.J.S.en
dc.description.abstractSummary. Marine picocyanobacteria of the genera Prochlorococcus and Synechococcus are the most numerous photosynthetic organisms on our planet [1, 2]. With a global population size of 3.6 × 1027 [3], they are responsible for approximately 10% of global primary production [3, 4]. Viruses that infect Prochlorococcus and Synechococcus (cyanophages) can be readily isolated from ocean waters [5–7] and frequently outnumber their cyanobacterial hosts [8]. Ultimately, cyanophage-induced lysis of infected cells results in the release of fixed carbon into the dissolved organic matter pool [9]. What is less well known is the functioning of photosynthesis during the relatively long latent periods of many cyanophages [10, 11]. Remarkably, the genomes of many cyanophage isolates contain genes involved in photosynthetic electron transport (PET) [12–18] as well as central carbon metabolism [14, 15, 19, 20], suggesting that cyanophages may play an active role in photosynthesis. However, cyanophage-encoded gene products are hypothesized to maintain or even supplement PET for energy generation while sacrificing wasteful CO2 fixation during infection [17, 18, 20]. Yet this paradigm has not been rigorously tested. Here, we measured the ability of viral-infected Synechococcus cells to fix CO2 as well as maintain PET. We compared two cyanophage isolates that share different complements of PET and central carbon metabolism genes. We demonstrate cyanophage-dependent inhibition of CO2 fixation early in the infection cycle. In contrast, PET is maintained throughout infection. Our data suggest a generalized strategy among marine cyanophages to redirect photosynthesis to support phage development, which has important implications for estimates of global primary production.
dc.relation.ispartofCurrent Biologyen
dc.subjectQH301 Biologyen
dc.subjectSDG 14 - Life Below Wateren
dc.titleViruses inhibit CO2 fixation in the most abundant phototrophs on Earthen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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