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dc.contributor.authorPettigrew, Kerry Andrea
dc.contributor.authorFrinton, Emily
dc.contributor.authorNudel, Ron
dc.contributor.authorChan, May T. M.
dc.contributor.authorThompson, Paul
dc.contributor.authorHayiou-Thomas, Marianna E.
dc.contributor.authorTalcott, Joel B.
dc.contributor.authorStein, John
dc.contributor.authorMonaco, Anthony P.
dc.contributor.authorHulme, Charles
dc.contributor.authorSnowling, Margaret J.
dc.contributor.authorNewbury, Diane F.
dc.contributor.authorParacchini, Silvia
dc.date.accessioned2016-06-15T14:30:06Z
dc.date.available2016-06-15T14:30:06Z
dc.date.issued2016-06-14
dc.identifier.citationPettigrew , K A , Frinton , E , Nudel , R , Chan , M T M , Thompson , P , Hayiou-Thomas , M E , Talcott , J B , Stein , J , Monaco , A P , Hulme , C , Snowling , M J , Newbury , D F & Paracchini , S 2016 , ' Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes ' , Journal of Neurodevelopmental Disorders , vol. 8 , 24 . https://doi.org/10.1186/s11689-016-9157-6en
dc.identifier.issn1866-1947
dc.identifier.otherPURE: 243223214
dc.identifier.otherPURE UUID: 7f8a8459-d6f0-4b3d-bd1b-7fb6c27486df
dc.identifier.otherScopus: 84975166180
dc.identifier.otherORCID: /0000-0001-9934-8602/work/60428104
dc.identifier.otherWOS: 000377788200001
dc.identifier.urihttp://hdl.handle.net/10023/8991
dc.descriptionSP is a Royal Society University Research Fellow. Support to the analysis was provided by the St Andrews Bioinformatics Unit funded by the Wellcome Trust [grant 097831/Z/11/Z]. Analysis of the cohort was supported by a Wellcome Trust Programme Grant to MJS [WT082032MA]. EF is the recipient of a Wolfson Intercalated Award. MTMC is the recipient of the Wilkinson Junior Research Fellowship at Worcester College, Oxford and was funded by the Esther Yewpick Lee Millennium Scholarship. RN was funded by a University of Oxford Nuffield Department of Medicine Prize Studentship. DFN is an MRC Career Development Fellow. The work of the Newbury lab is funded by the Medical Research Council [G1000569/1 and MR/J003719/1]. The work of the Wellcome Trust Centre in Oxford is supported by the Wellcome Trust [090532/Z/09/Z].en
dc.description.abstractBackground: Specific Language Impairment (SLI) is a common neurodevelopmental disorder, observed in 5-10% of children. Family and twin studies suggest a strong genetic component, but relatively few candidate genes have been reported to date. A recent genome-wide association study (GWAS) described the first statistically significant association specifically for a SLI cohort between a missense variant (rs4280164) in the NOP9 gene and language-related phenotypes under a parent-of-origin model. Replications of these findings are particularly challenging because the availability of parental DNA is required. Methods: We used two independent family-based cohorts characterised with reading- and language-related traits: a longitudinal cohort (n = 106 informative families) including children with language and reading difficulties and a nuclear family cohort (n = 264 families) selected for dyslexia. Results: We observed association with languagerelated measures when modelling for parent-of-origin effects at the NOP9 locus in both cohorts: minimum P = 0.001 for phonological awareness with a paternal effect in the first cohort and minimum P = 0.0004 for irregular word reading with a maternal effect in the second cohort. Allelic and parental trends were not consistent when compared to the original study. Conclusions: A parent-of-origin effect at this locus was detected in both cohorts, albeit with different trends. These findings contribute in interpreting the original GWAS report and support further investigations of the NOP9 locus and its role in language-related traits. A systematic evaluation of parent-of-origin effects in genetic association studies has the potential to reveal novel mechanisms underlying complex traits.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofJournal of Neurodevelopmental Disordersen
dc.rights© 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectLanguage impairementen
dc.subjectDyslexiaen
dc.subjectGenetic associationen
dc.subjectParent-of-originen
dc.subjectCandidate geneen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectNDASen
dc.subject.lccRC0321en
dc.titleFurther evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1186/s11689-016-9157-6
dc.description.statusPeer revieweden


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