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dc.contributor.authorScolding, Neil
dc.contributor.authorBarnes, David
dc.contributor.authorCader, Sarah
dc.contributor.authorChataway, Jeremy
dc.contributor.authorChaudhuri, Abhijit
dc.contributor.authorColes, Alasdair
dc.contributor.authorGiovannoni, Gavin
dc.contributor.authorMiller, David
dc.contributor.authorRashid, Waqar
dc.contributor.authorSchmierer, Klaus
dc.contributor.authorShehu, Abdullah
dc.contributor.authorSilber, Eli
dc.contributor.authorYoung, Carolyn
dc.contributor.authorZajicek, John
dc.identifier.citationScolding , N , Barnes , D , Cader , S , Chataway , J , Chaudhuri , A , Coles , A , Giovannoni , G , Miller , D , Rashid , W , Schmierer , K , Shehu , A , Silber , E , Young , C & Zajicek , J 2015 , ' Association of British Neurologists : revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosis ' , Practical Neurology , vol. 15 , no. 4 , pp. 273-279 .
dc.identifier.otherPURE: 242546079
dc.identifier.otherPURE UUID: 923249a3-fc7f-4824-9d6f-48aff140be42
dc.identifier.otherPubMed: 26101071
dc.identifier.otherScopus: 84937402267
dc.identifier.otherPubMed: 26101071
dc.identifier.otherORCID: /0000-0003-3481-825X/work/64034721
dc.description.abstractIn June 1999, the Association of British Neurologists (ABN) first published guidelines for the use of the licensed multiple sclerosis (MS) disease-modifying treatments (at that time β-interferon and glatiramer acetate). The guidelines were revised in 2001 and have been periodically updated since then. In 2002, following the negative assessment of these treatments by the National Institute for Health and Care Excellence (NICE), the MS risk-sharing scheme started, in which patients eligible according to the 2001 ABN guidelines were provided with treatment funded through the UK National Health Service (NHS), and monitored annually for up to 10 years.1 Recruitment to the risk-sharing scheme cohort is complete. Pending a future final evaluation, the UK Department of Health's instruction to NHS funders remains in place: that patients who fulfil the ABN criteria should continue to receive treatment funded through the NHS. The British neurological community has fully accepted the risk-sharing scheme for prescribing β-interferon and glatiramer acetate. Approximately 70 ‘treating centres’ have recruited >5000 patients between 2002 and 2005, and these have been monitored annually for 10 years; many more patients have received these treatments since 2005. The ABN published revised guidelines in 2007, and then again in 2009, following the licensing of natalizumab and mitoxantrone. This 2015 revised guideline replaces former versions. It includes all newly approved or licensed treatments for MS and represents a consensus concerning their use. These guidelines will require future revision as other treatments receive approval (eg, daclizumab and ocrelizumab): we suggest they are reviewed after an interval of no longer than 12 months. The guideline is not intended to provide a complete description of the possible complications and monitoring of disease-modifying treatments in MS; we refer prescribing neurologists to the relevant summaries of product characteristics.
dc.relation.ispartofPractical Neurologyen
dc.rights© 2015, the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at /
dc.subjectDisease Managementen
dc.subjectDrug Prescriptionsen
dc.subjectGreat Britainen
dc.subjectGuidelines as Topicen
dc.subjectMultiple Sclerosisen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleAssociation of British Neurologists : revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosisen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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