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dc.contributor.authorBozek, Katarzyna
dc.contributor.authorWei, Yuning
dc.contributor.authorYan, Zheng
dc.contributor.authorLiu, Xiling
dc.contributor.authorXiong, Jieyi
dc.contributor.authorSugimoto, Masahiro
dc.contributor.authorTomita, Masaru
dc.contributor.authorPaeaebo, Svante
dc.contributor.authorPieszek, Raik
dc.contributor.authorSherwood, Chet C.
dc.contributor.authorHof, Patrick R.
dc.contributor.authorEly, John J.
dc.contributor.authorSteinhauser, Dirk
dc.contributor.authorWillmitzer, Lothar
dc.contributor.authorBangsbo, Jens
dc.contributor.authorHansson, Ola
dc.contributor.authorCall, Josep
dc.contributor.authorGiavalisco, Patrick
dc.contributor.authorKhaitovich, Philipp
dc.date.accessioned2016-05-31T11:30:04Z
dc.date.available2016-05-31T11:30:04Z
dc.date.issued2014-05-27
dc.identifier.citationBozek , K , Wei , Y , Yan , Z , Liu , X , Xiong , J , Sugimoto , M , Tomita , M , Paeaebo , S , Pieszek , R , Sherwood , C C , Hof , P R , Ely , J J , Steinhauser , D , Willmitzer , L , Bangsbo , J , Hansson , O , Call , J , Giavalisco , P & Khaitovich , P 2014 , ' Exceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniqueness ' , PLoS Biology , vol. 12 , no. 5 , e1001871 . https://doi.org/10.1371/journal.pbio.1001871en
dc.identifier.issn1545-7885
dc.identifier.otherPURE: 141912469
dc.identifier.otherPURE UUID: 1f213dd8-5620-43e0-bfca-2d3b32cb58d0
dc.identifier.otherWOS: 000336969200021
dc.identifier.otherScopus: 84901435099
dc.identifier.otherORCID: /0000-0002-8597-8336/work/37477850
dc.identifier.urihttp://hdl.handle.net/10023/8902
dc.description.abstractMetabolite concentrations reflect the physiological states of tissues and cells. However, the role of metabolic changes in species evolution is currently unknown. Here, we present a study of metabolome evolution conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque monkeys, and mice based on over 10,000 hydrophilic compounds. While chimpanzee, macaque, and mouse metabolomes diverge following the genetic distances among species, we detect remarkable acceleration of metabolome evolution in human prefrontal cortex and skeletal muscle affecting neural and energy metabolism pathways. These metabolic changes could not be attributed to environmental conditions and were confirmed against the expression of their corresponding enzymes. We further conducted muscle strength tests in humans, chimpanzees, and macaques. The results suggest that, while humans are characterized by superior cognition, their muscular performance might be markedly inferior to that of chimpanzees and macaque monkeys.
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofPLoS Biologyen
dc.rights© 2014 Bozek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectMass-spectrometryen
dc.subjectPan-troglodytesen
dc.subjectChimpanzeeen
dc.subjectMetabolitesen
dc.subjectStrengthen
dc.subjectHomoen
dc.subjectQL Zoologyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject.lccQLen
dc.subject.lccRC0321en
dc.titleExceptional evolutionary divergence of human muscle and brain metabolomes parallels human cognitive and physical uniquenessen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews.Centre for Social Learning & Cognitive Evolutionen
dc.identifier.doihttps://doi.org/10.1371/journal.pbio.1001871
dc.description.statusPeer revieweden
dc.identifier.urlhttp://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001871#s5en


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