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Inorganic sulfur-nitrogen compounds : from gunpowder chemistry to the forefront of biological signaling
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dc.contributor.author | Cortese-Krott, Miriam M. | |
dc.contributor.author | Butler, Anthony Robert | |
dc.contributor.author | Woollins, J. Derek | |
dc.contributor.author | Feelisch , Martin | |
dc.date.accessioned | 2016-05-10T11:30:04Z | |
dc.date.available | 2016-05-10T11:30:04Z | |
dc.date.issued | 2016-04-14 | |
dc.identifier.citation | Cortese-Krott , M M , Butler , A R , Woollins , J D & Feelisch , M 2016 , ' Inorganic sulfur-nitrogen compounds : from gunpowder chemistry to the forefront of biological signaling ' , Dalton Transactions , vol. 45 , no. 14 , pp. 5908-5919 . https://doi.org/10.1039/C5DT05034K | en |
dc.identifier.issn | 1477-9226 | |
dc.identifier.other | PURE: 241405645 | |
dc.identifier.other | PURE UUID: 4c8eebca-8803-410b-887f-2ed75ca5948d | |
dc.identifier.other | Scopus: 84963777456 | |
dc.identifier.other | ORCID: /0000-0002-1498-9652/work/31779165 | |
dc.identifier.other | WOS: 000373630800004 | |
dc.identifier.uri | https://hdl.handle.net/10023/8766 | |
dc.description | The authors gratefully acknowledge support from the German Research Council (DFG CO 1305/2-1 and SFB1116 TP B06 to MCK), the Susanne-Bunnenberg-Stiftung of the Düsseldorf Heart Center (to MK, and MCK) and the Forschungskommission, Faculty of Medicine, Heinrich Heine University of Düsseldorf (to MCK), the UK Medical Research Council (G1001536 to MF), and the Faculty of Medicine, University of Southampton (to MF). | en |
dc.description.abstract | The reactions between inorganic sulfur and nitrogen-bearing compound to form S-N containing species have a long history and, besides assuming importance in industrial synthetic processes, are of relevance to microbial metabolism; waste water treatment; aquatic, soil and atmospheric chemistry; and combustion processes. The recent discovery that hydrogen sulfide and nitric oxide exert often similar, sometimes mutually dependent effects in a variety of biological systems, and that the chemical interaction of these two species leads to formation of S-N compounds brought this chemistry to the attention of physiologists, biochemists and physicians. We here provide a perspective about the potential role of S-N compounds in biological signaling and briefly review their chemical properties and bioactivities in the context of the chronology of their discovery. Studies of the biological role of NO revealed why its chemistry is ideally suited for the tasks Nature has chosen for it; realising how the distinctive properties of sulfur can enrich this bioactivity does much to revive ‘die Freude am experimentellen Spiel’ of the pioneers in this field. | |
dc.format.extent | 12 | |
dc.language.iso | eng | |
dc.relation.ispartof | Dalton Transactions | en |
dc.rights | This is an Open Access article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | Inorganic sulfur-nitrogen compounds : from gunpowder chemistry to the forefront of biological signaling | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Office of the Principal | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1039/C5DT05034K | |
dc.description.status | Peer reviewed | en |
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