Files in this item
The role of delamanid in the treatment of drug-resistant tuberculosis
Item metadata
dc.contributor.author | Lewis, Joseph M. | |
dc.contributor.author | Sloan, Derek James | |
dc.date.accessioned | 2016-04-20T15:16:56Z | |
dc.date.available | 2016-04-20T15:16:56Z | |
dc.date.issued | 2015-05-13 | |
dc.identifier.citation | Lewis , J M & Sloan , D J 2015 , ' The role of delamanid in the treatment of drug-resistant tuberculosis ' , Therapeutics and Clinical Risk Management , vol. 11 , pp. 779-791 . https://doi.org/10.2147/TCRM.S71076 | en |
dc.identifier.issn | 1176-6336 | |
dc.identifier.other | PURE: 241921046 | |
dc.identifier.other | PURE UUID: 14bb6867-58b1-42e4-97bc-8c9bf0210ef6 | |
dc.identifier.other | Scopus: 84930204442 | |
dc.identifier.uri | https://hdl.handle.net/10023/8654 | |
dc.description.abstract | Tuberculosis (TB) remains a significant cause of death worldwide, and emergence of drug-resistant TB requires lengthy treatments with toxic drugs that are less effective than their first-line equivalents. New treatments are urgently needed. Delamanid, previously OPC-67863, is a novel drug of the dihydro-nitroimidazole class with potent anti-TB activity and great promise to be effective in the treatment of drug-resistant TB. This review examines the preclinical and clinical development of delamanid, reviews current guidance on its use and evaluates the opportunities and challenges for its future role in TB management. | |
dc.format.extent | 13 | |
dc.language.iso | eng | |
dc.relation.ispartof | Therapeutics and Clinical Risk Management | en |
dc.rights | © 2015 Lewis and Sloan. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. | en |
dc.subject | Delamanid | en |
dc.subject | OPC-67683 | en |
dc.subject | Tuberculosis | en |
dc.subject | Drug resistance | en |
dc.subject | MDR-TB | en |
dc.subject | RA0421 Public health. Hygiene. Preventive Medicine | en |
dc.subject | RS Pharmacy and materia medica | en |
dc.subject | Pharmacology (medical) | en |
dc.subject | Medicine(all) | en |
dc.subject | Pharmacology, Toxicology and Pharmaceutics(all) | en |
dc.subject | Safety Research | en |
dc.subject | Chemical Health and Safety | en |
dc.subject | SDG 3 - Good Health and Well-being | en |
dc.subject.lcc | RA0421 | en |
dc.subject.lcc | RS | en |
dc.title | The role of delamanid in the treatment of drug-resistant tuberculosis | en |
dc.type | Journal item | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | https://doi.org/10.2147/TCRM.S71076 | |
dc.description.status | Peer reviewed | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.