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Fluorine containing amino acids : synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif
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dc.contributor.author | Ayoup , Mohammed Salah | |
dc.contributor.author | Cordes, David Bradford | |
dc.contributor.author | Slawin, Alexandra Martha Zoya | |
dc.contributor.author | O'Hagan, David | |
dc.date.accessioned | 2016-04-15T15:52:08Z | |
dc.date.available | 2016-04-15T15:52:08Z | |
dc.date.issued | 2015-05-28 | |
dc.identifier | 181272011 | |
dc.identifier | 0f4d008e-57c2-4d13-b9b8-5f3e00ada914 | |
dc.identifier | 84929376570 | |
dc.identifier | 000354438400009 | |
dc.identifier.citation | Ayoup , M S , Cordes , D B , Slawin , A M Z & O'Hagan , D 2015 , ' Fluorine containing amino acids : synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif ' , Organic & Biomolecular Chemistry , vol. 13 , no. 20 , pp. 5621-5624 . https://doi.org/10.1039/C5OB00650C | en |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | ORCID: /0000-0002-5366-9168/work/28024000 | |
dc.identifier.other | ORCID: /0000-0002-9527-6418/work/56861404 | |
dc.identifier.other | ORCID: /0000-0002-0510-5552/work/68281212 | |
dc.identifier.uri | https://hdl.handle.net/10023/8616 | |
dc.description | MA thanks the Egyptian Government for a Scholarship. DO’H thanks the Royal Society for a Royal Society Wolfson Research Merit Award. | en |
dc.description.abstract | A synthesis of two (S)-phenylalanine derivatives is described which have the all-cis, 2,3,5,6-tetrafluorocyclohexyl motif attached to the aromatic ring at the meta and para positions; the para substituted isomer is elaborated into illustrative dipeptides via the free amine and carboxylate respectively demonstrating its utility as a novel amino acid for peptide synthesis and offering a vehicle for incorporation of this unique and facially polarized ring system into bioactive compounds. | |
dc.format.extent | 214800 | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.subject | QD Chemistry | en |
dc.subject | DAS | en |
dc.subject.lcc | QD | en |
dc.title | Fluorine containing amino acids : synthesis and peptide coupling of amino acids containing the all-cis tetrafluorocyclohexyl motif | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.1039/C5OB00650C | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2016-04-15 | |
dc.identifier.grantnumber | EP/K031252/1 | en |
dc.identifier.grantnumber | EP/K039210/1 | en |
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