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dc.contributor.authorMacnamara, Cicely Krystyna
dc.contributor.authorEftimie, Raluca
dc.date.accessioned2016-04-12T23:01:50Z
dc.date.available2016-04-12T23:01:50Z
dc.date.issued2015-07-21
dc.identifier.citationMacnamara , C K & Eftimie , R 2015 , ' Memory versus effector immune responses in oncolytic virotherapies ' , Journal of Theoretical Biology , vol. 377 , pp. 1-9 . https://doi.org/10.1016/j.jtbi.2015.04.004en
dc.identifier.issn0022-5193
dc.identifier.otherPURE: 240256741
dc.identifier.otherPURE UUID: 3a1184d8-5030-451e-946b-79eba3f8720d
dc.identifier.otherScopus: 84928642630
dc.identifier.otherORCID: /0000-0003-4961-6052/work/27162489
dc.identifier.urihttp://hdl.handle.net/10023/8604
dc.descriptionR.E. acknowledges support from an Engineering and Physical Sciences Research Council (UK) First Grant number EP/K033689/1en
dc.description.abstractThe main priority when designing cancer immuno-therapies has been to seek viable biological mechanisms that lead to permanent cancer eradication or cancer control. Understanding the delicate balance between the role of effector and memory cells on eliminating cancer cells remains an elusive problem in immunology. Here we make an initial investigation into this problem with the help of a mathematical model for oncolytic virotherapy; although the model can in fact be made general enough to be applied also to other immunological problems. Our results show that long-term cancer control is associated with a large number of persistent effector cells (irrespective of the initial peak in effector cell numbers). However, this large number of persistent effector cells is sustained by a relatively large number of memory cells. Moreover, we show that cancer control from a dormant state cannot be predicted by the size of the memory population.
dc.language.isoeng
dc.relation.ispartofJournal of Theoretical Biologyen
dc.rights© 2015, Publisher / the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.sciencedirect.com / https://dx.doi.org/10.1016/j.jtbi.2015.04.004en
dc.subjectCancer modellingen
dc.subjectEffector and memory cellsen
dc.subjectTumour controlen
dc.subjectCancer dormancyen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQA Mathematicsen
dc.subjectNDASen
dc.subject.lccRC0254en
dc.subject.lccQAen
dc.titleMemory versus effector immune responses in oncolytic virotherapiesen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.Applied Mathematicsen
dc.identifier.doihttps://doi.org/10.1016/j.jtbi.2015.04.004
dc.description.statusPeer revieweden
dc.date.embargoedUntil2016-04-13


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