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dc.contributor.advisorPhilp, Douglas
dc.contributor.authorSadownik, Jan
dc.coverage.spatialvii, 240en_US
dc.date.accessioned2010-02-05T16:31:24Z
dc.date.available2010-02-05T16:31:24Z
dc.date.issued2009
dc.identifieruk.bl.ethos.552343
dc.identifier.urihttps://hdl.handle.net/10023/857
dc.description.abstractUntil very recently, synthetic chemistry has focussed on the creation of chemical entities with desirable properties through the programmed application of isolated chemical reactions, either individually or in a cascade that afford a target compound selectively. By contrast, biological systems operate using a plethora of complex interconnected signaling and metabolic networks with multiple checkpoint controls and feedback loops allowing biological systems to adapt and respond rapidly to external stimuli. Systems chemistry attempts to capture the complexity and emergent phenomena prevalent in the life sciences within a wholly synthetic chemical framework. In this approach, complex phenomena are expressed by a group of synthetic chemical entities designed to interact and react with many partners within the ensemble in programmed ways. In this manner, it should be possible to create synthetic chemical systems whose properties are not simply the linear sum of the attributes of the individual components. Chapter 1 discusses the role of complex networks in various aspects of chemistry- related research from the origin of life to nanotechnology. Further, it introduces the concept of Systems chemistry, giving various examples of dynamic covalent networks, self-replicating systems and molecular logic gates, showing the applications of complex system research. Chapter 2 discusses the components of replicator design. Further, it introduces a network based on recognition mediated reactions that is implemented by length- segregation of the substrates and displays properties of self-sorting. Chapter 3 presents a fully addressable chemical system based on auto- and cross- catalytic properties of product templates. The system is described by Boolean logic operations with different template inputs giving different template outputs. Chapter 4 introduces a dynamic network which fate is determined by a single recognition event. The replicator is capable of exploiting and dominating the exchanging pool of reagents in order to amplify its own formation at the expense of other species through the non-linear kinetics inherent in minimal replication. Chapter 5 focuses on the development of complex dynamic systems from structurally simple molecules. The new approach allows creating multicomponent networks with many reaction pathways operating simultaneously from readily available substrates.en_US
dc.language.isoenen_US
dc.publisherUniversity of St Andrews
dc.subject.lccQD262.S2
dc.subject.lcshOrganic compounds--Synthesisen
dc.subject.lcshNonlinear systemsen
dc.subject.lcshCombinatorial chemistryen
dc.subject.lcshBiocomplexityen
dc.subject.lcshMolecular recognitionen
dc.titleEvolving complex systems from simple moleculesen_US
dc.typeThesisen_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US


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