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Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one

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Aitken_2015_Syn_Synthesis_AM.pdf (258.1Kb)
Date
01/06/2015
Author
Aitken, R Alan
Meehan, Anna
Power, Lynn Anita
Keywords
Chiral pool
Stereoselective synthesis
(R)-lactic acid
(R)-alanine
Diazotization
1,3-dioxolan-4-one
QD Chemistry
NDAS
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Abstract
A convenient procedure for the synthesis of very expensive (R)-lactic acid from relatively inexpensive (R)-alanine is described. Its subsequent conversion into a chiral dioxolanone can be carried out by using an inexpensive pivalaldehyde–tert-butanol mixture.
Citation
Aitken , R A , Meehan , A & Power , L A 2015 , ' Synthesis of (R)-Lactic Acid and (2R,5R)-2-tert-Butyl-5-methyl-1,3-dioxolan-4-one ' , Synthesis , vol. 47 , no. 11 , pp. 1557-1559 . https://doi.org/10.1055/s-0034-1380511
Publication
Synthesis
Status
Peer reviewed
DOI
https://doi.org/10.1055/s-0034-1380511
ISSN
0039-7881
Type
Journal article
Rights
© Georg Thieme Verlag Stuttgart - New York. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at http://dx.doi.org/10.1055/s-0034-1380511
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  • University of St Andrews Research
URI
http://hdl.handle.net/10023/8545

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