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dc.contributor.authorVidonne, Annick
dc.contributor.authorKosikova, Tamara
dc.contributor.authorPhilp, Douglas
dc.identifier.citationVidonne , A , Kosikova , T & Philp , D 2016 , ' Exploiting recognition-mediated assembly and reactivity in [2]rotaxane formation ' , Chemical Science , vol. 7 , no. 4 , pp. 2592-2603 .
dc.identifier.otherPURE: 240255926
dc.identifier.otherPURE UUID: 2ae3c3b2-f7da-4b7c-8e31-743e9c674906
dc.identifier.otherScopus: 84962321118
dc.identifier.otherORCID: /0000-0002-9198-4302/work/56639234
dc.identifier.otherWOS: 000372614800016
dc.descriptionThe authors thank EaStCHEM (Graduate Studentship to AV), EPSRC (Graduate Studentship to TK, Grant EP/K503162/1) and the University of St Andrews for financial support.en
dc.description.abstractA small molecular reaction network exploits recognition-mediated reactive processes in order to drive the assembly and formation of both a self-replicating linear template (thread) and a [2]rotaxane, in which the linear template is encircled by a diamide macrocycle. Complementary recognition sites, placed at strategic positions on the reactive building blocks, drive these assembly and replication processes. Template-instructed experiments show that the thread is capable of efficient self-replication and that no cross-catalytic relationships exist between thread and the [2]rotaxane. The rate of [2]rotaxane formation is insensitive to the addition of preformed template, however, [2]rotaxane formation does show enhanced diastereoselectivity, most likely originating from its recognition- mediated formation through a binary reactive complex.
dc.relation.ispartofChemical Scienceen
dc.rightsCopyright 2016 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (
dc.subjectQD Chemistryen
dc.titleExploiting recognition-mediated assembly and reactivity in [2]rotaxane formationen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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