Accurate extraction of nanometer distances in multimers by pulse EPR
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Pulse electron paramagnetic resonance (EPR) is gaining increasing importance in structural biology. The PELDOR (pulsed electron-electron double resonance) method allows extracting distance information on the nanometer scale. Here, we demonstrate the efficient extraction of distances from multimeric systems such as membrane embedded ion channels where data analysis is commonly hindered by multi-spin effects.
Valera , S , Ackermann , K , Pliotas , C , Huang , H , Naismith , J H & Bode , B E 2016 , ' Accurate extraction of nanometer distances in multimers by pulse EPR ' , Chemistry - A European Journal , vol. 22 , no. 14 , pp. 4700–4703 . https://doi.org/10.1002/chem.201505143
Chemistry - A European Journal
Copyright 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DescriptionB.E.B. is grateful for funding from the European Union (REA 334496). This work was supported by the EPSRC (EP/M024660/1), the Wellcome Trust [099149/Z/12/Z], and the Royal Society (RG140723).
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