Tuning the Nitric Oxide release from CPO-27 MOFs
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Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications.
Cattaneo , D , Warrender , S J , Duncan , M J , Kelsall , C , Doherty , M , Whitfield , P , Megson , I & Morris , R E 2016 , ' Tuning the Nitric Oxide release from CPO-27 MOFs ' RSC Advances , vol 6 , no. 17 , pp. 14059-14067 . DOI: 10.1039/C5RA24023A
Copyright 2016 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
The authors gratefully acknowledge the funding of this work from Scottish Enterprise (POC13), the EPSRC (EP/K025112/1), the British Heart Foundation (NH/11/8/29253) and the Royal Society (Brian Mercer Award for Innovation - MI120033). Date of Acceptance: 17/01/2016