A recognition-mediated reaction drives amplification within a dynamic library
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A single, appropriately designed, recognition event targets and transforms one of two reactive members of an exchanging pool of compounds through a recognition-mediated irreversible cycloaddition reaction, altering dramatically the final composition and kinetic behaviour of the dynamic library.
Sadownik , J W & Philp , D 2015 , ' A recognition-mediated reaction drives amplification within a dynamic library ' Organic & Biomolecular Chemistry , vol 13 , no. 41 , pp. 10392-10401 . DOI: 10.1039/C5OB01621E
Organic & Biomolecular Chemistry
Copyright 2015 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
The authors thank EaStCHEM (Graduate Studentship to JWS) and the University of St Andrews for financial support.