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Bioabsorbable polymer optical waveguides for deep-tissue photomedicine
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dc.contributor.author | Nizamoglu, Sedat | |
dc.contributor.author | Gather, Malte Christian | |
dc.contributor.author | Humar, Matjaž | |
dc.contributor.author | Choi, Myunghwan | |
dc.contributor.author | Kim, Seonghoon | |
dc.contributor.author | Kim, Ki Su | |
dc.contributor.author | Hahn, Sei Kwang | |
dc.contributor.author | Scarcelli, Giuliano | |
dc.contributor.author | Randolph, Mark | |
dc.contributor.author | Redmond, Robert W. | |
dc.contributor.author | Yun, Seok Hyun | |
dc.date.accessioned | 2016-02-01T21:10:05Z | |
dc.date.available | 2016-02-01T21:10:05Z | |
dc.date.issued | 2016-01-19 | |
dc.identifier.citation | Nizamoglu , S , Gather , M C , Humar , M , Choi , M , Kim , S , Kim , K S , Hahn , S K , Scarcelli , G , Randolph , M , Redmond , R W & Yun , S H 2016 , ' Bioabsorbable polymer optical waveguides for deep-tissue photomedicine ' , Nature Communications , vol. 7 , 10374 . https://doi.org/10.1038/ncomms10374 | en |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | PURE: 240426515 | |
dc.identifier.other | PURE UUID: b33be981-8bfa-41cf-9cfc-1611723ec224 | |
dc.identifier.other | Scopus: 84959306826 | |
dc.identifier.other | ORCID: /0000-0002-4857-5562/work/47136513 | |
dc.identifier.other | WOS: 000369022100011 | |
dc.identifier.uri | https://hdl.handle.net/10023/8110 | |
dc.description | This work was funded by the U.S. National Institutes of Health (R21EB013761, P41EB015903, R01CA192878), Department of Defense (FA9550-13-1-0068), Bullock-Wellman Fellowships, Marie Curie Career Integration Grant (631679), Marie Curie International Outgoing Fellowship No. 627274 within the 7th European Community Framework Programme, Human Frontier Science Program (Young Investigator Grant RGY0074/2013), the Bio & Medical Technology Development Program of the National Research Foundation of Korea (2012M3A9C6049791) and the IT Consilience Creative Program of MKE and NIPA (IITP-2015-R0346-15-1007). | en |
dc.description.abstract | Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues. | |
dc.format.extent | 7 | |
dc.language.iso | eng | |
dc.relation.ispartof | Nature Communications | en |
dc.rights | Copyright (c) 2016, the authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Photonics | en |
dc.subject | QC Physics | en |
dc.subject | NDAS | en |
dc.subject.lcc | QC | en |
dc.title | Bioabsorbable polymer optical waveguides for deep-tissue photomedicine | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1038/ncomms10374 | |
dc.description.status | Peer reviewed | en |
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