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dc.contributor.authorNizamoglu, Sedat
dc.contributor.authorGather, Malte Christian
dc.contributor.authorHumar, Matjaž
dc.contributor.authorChoi, Myunghwan
dc.contributor.authorKim, Seonghoon
dc.contributor.authorKim, Ki Su
dc.contributor.authorHahn, Sei Kwang
dc.contributor.authorScarcelli, Giuliano
dc.contributor.authorRandolph, Mark
dc.contributor.authorRedmond, Robert W.
dc.contributor.authorYun, Seok Hyun
dc.date.accessioned2016-02-01T21:10:05Z
dc.date.available2016-02-01T21:10:05Z
dc.date.issued2016-01-19
dc.identifier.citationNizamoglu , S , Gather , M C , Humar , M , Choi , M , Kim , S , Kim , K S , Hahn , S K , Scarcelli , G , Randolph , M , Redmond , R W & Yun , S H 2016 , ' Bioabsorbable polymer optical waveguides for deep-tissue photomedicine ' , Nature Communications , vol. 7 , 10374 . https://doi.org/10.1038/ncomms10374en
dc.identifier.issn2041-1723
dc.identifier.otherPURE: 240426515
dc.identifier.otherPURE UUID: b33be981-8bfa-41cf-9cfc-1611723ec224
dc.identifier.otherScopus: 84959306826
dc.identifier.otherORCID: /0000-0002-4857-5562/work/47136513
dc.identifier.otherWOS: 000369022100011
dc.identifier.urihttp://hdl.handle.net/10023/8110
dc.descriptionThis work was funded by the U.S. National Institutes of Health (R21EB013761, P41EB015903, R01CA192878), Department of Defense (FA9550-13-1-0068), Bullock-Wellman Fellowships, Marie Curie Career Integration Grant (631679), Marie Curie International Outgoing Fellowship No. 627274 within the 7th European Community Framework Programme, Human Frontier Science Program (Young Investigator Grant RGY0074/2013), the Bio & Medical Technology Development Program of the National Research Foundation of Korea (2012M3A9C6049791) and the IT Consilience Creative Program of MKE and NIPA (IITP-2015-R0346-15-1007).en
dc.description.abstractAdvances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.rightsCopyright (c) 2016, the authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en
dc.subjectPhotonicsen
dc.subjectQC Physicsen
dc.subjectNDASen
dc.subject.lccQCen
dc.titleBioabsorbable polymer optical waveguides for deep-tissue photomedicineen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1038/ncomms10374
dc.description.statusPeer revieweden


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