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A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the development and treatment of Alzheimer’s disease
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dc.contributor.author | Benek, Ondrej | |
dc.contributor.author | Aitken, Laura | |
dc.contributor.author | Hroch, Lukas | |
dc.contributor.author | Kuca, Kamil | |
dc.contributor.author | Gunn-Moore, Frank J | |
dc.contributor.author | Musilek, Kamil | |
dc.date.accessioned | 2016-02-01T00:11:45Z | |
dc.date.available | 2016-02-01T00:11:45Z | |
dc.date.issued | 2015 | |
dc.identifier | 161500640 | |
dc.identifier | fc508e88-d248-450b-9321-6fcacbaa7443 | |
dc.identifier | 84931268553 | |
dc.identifier | 000350477600002 | |
dc.identifier.citation | Benek , O , Aitken , L , Hroch , L , Kuca , K , Gunn-Moore , F J & Musilek , K 2015 , ' A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the development and treatment of Alzheimer’s disease ' , Current Medicinal Chemistry , vol. 22 , no. 9 , pp. 1056-1085 . https://doi.org/10.2174/0929867322666150114163051 | en |
dc.identifier.issn | 0929-8673 | |
dc.identifier.other | ORCID: /0000-0003-3422-3387/work/34730424 | |
dc.identifier.other | ORCID: /0000-0001-7259-4491/work/31318398 | |
dc.identifier.uri | https://hdl.handle.net/10023/8102 | |
dc.description | This work was supported by the Ministry of Education, Youth and Sports CZ (no. LD14009, no. SV/FVZ201201, no. SVV260062), COST CM1103, MH CZ - DRO (UHHK, 00179906), The Alzheimer’s Society, The Barcopel Foundation and the MSD Scottish Life Sciences fund. | en |
dc.description.abstract | The amyloid-β peptide (Aβ) has been associated with Alzheimer’s disease (AD) for decades. The original amyloid cascade hypothesis declared that the insoluble extracellular plaques were responsible for Aβ toxicity. Later, this hypothesis has been updated and soluble intracellular Aβ forms and their effects within the cell have come into focus. Mitochondrial dysfunction plays an important role in the pathophysiology of AD. Aβ was detected inside mitochondria and several mitochondrial proteins were found to interact directly with Aβ. Such interactions can affect a protein’s function and cause damage to the mitochondria and finally to the whole cell. This review summarizes the current knowledge of mitochondrial proteins directly interacting with Aβ and discusses their significance for the development of therapeutics in the treatment of AD. | |
dc.format.extent | 30 | |
dc.format.extent | 1271364 | |
dc.language.iso | eng | |
dc.relation.ispartof | Current Medicinal Chemistry | en |
dc.subject | Alzheimer's disease | en |
dc.subject | Amyloid-beta peptide | en |
dc.subject | Drug target | en |
dc.subject | Enzyme inhibition | en |
dc.subject | Mitochondria | en |
dc.subject | Pharmacotherapy | en |
dc.subject | QH301 Biology | en |
dc.subject | I-PW | en |
dc.subject.lcc | QH301 | en |
dc.title | A direct interaction between mitochondrial proteins and amyloid-β peptide and its significance for the development and treatment of Alzheimer’s disease | en |
dc.type | Journal article | en |
dc.contributor.sponsor | Alzheimer's Society | en |
dc.contributor.sponsor | Scottish Funding Council | en |
dc.contributor.institution | University of St Andrews. School of Biology | en |
dc.contributor.institution | University of St Andrews. Institute of Behavioural and Neural Sciences | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | 10.2174/0929867322666150114163051 | |
dc.description.status | Peer reviewed | en |
dc.date.embargoedUntil | 2016-01-01 | |
dc.identifier.grantnumber | 188 PG-2012-172 | en |
dc.identifier.grantnumber | MSDPD03 | en |
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