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dc.contributor.authorStark, Daniel Graham
dc.contributor.authorO’Riordan, Timothy J. C.
dc.contributor.authorSmith, Andrew David
dc.identifier.citationStark , D G , O’Riordan , T J C & Smith , A D 2014 , ' Synthesis of di-, tri-, and tetrasubstituted pyridines from (phenylthio)carboxylic acids and 2-[aryl(tosylimino)methyl]acrylates ' , Organic Letters , vol. 16 , no. 24 , pp. 6496-6499 .
dc.identifier.otherPURE: 159433772
dc.identifier.otherPURE UUID: c91e152e-4141-4e04-ba20-1a92bc53a168
dc.identifier.otherScopus: 84919643291
dc.identifier.otherORCID: /0000-0002-2104-7313/work/36567505
dc.identifier.otherWOS: 000346759900059
dc.descriptionWe thank the Royal Society (ADS), Syngenta/EPSRC (DGS), and the EPSRC National Mass Spectrometry Facility at Swansea University.en
dc.description.abstractAn isothiourea-catalyzed Michael addition–lactamization followed by the sulfide oxidation–elimination/N- to O-sulfonyl transfer sequence for the formation of 2,3,5- and 2,3-substituted pyridine 6-tosylates from (phenylthio)acetic acids and α,β-unsaturated ketimines is described. Incorporation of the valuable 2-sulfonate group allows derivatization to a range of di-, tri-, and tetrasubstituted pyridines.
dc.relation.ispartofOrganic Lettersen
dc.rightsCopyright © 2014 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
dc.subjectQD Chemistryen
dc.titleSynthesis of di-, tri-, and tetrasubstituted pyridines from (phenylthio)carboxylic acids and 2-[aryl(tosylimino)methyl]acrylatesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.description.statusPeer revieweden

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