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dc.contributor.authorBecker, Jessica
dc.contributor.authorCzamara, Darina
dc.contributor.authorScerri, Tom S
dc.contributor.authorRamus, Franck
dc.contributor.authorCsépe, Valéria
dc.contributor.authorTalcott, Joel B
dc.contributor.authorStein, John
dc.contributor.authorMorris, Andrew
dc.contributor.authorLudwig, Kerstin U
dc.contributor.authorHoffmann, Per
dc.contributor.authorHonbolygó, Ferenc
dc.contributor.authorTóth, Dénes
dc.contributor.authorFauchereau, Fabien
dc.contributor.authorBogliotti, Caroline
dc.contributor.authorIannuzzi, Stéphanie
dc.contributor.authorChaix, Yves
dc.contributor.authorValdois, Sylviane
dc.contributor.authorBillard, Catherine
dc.contributor.authorGeorge, Florence
dc.contributor.authorSoares-Boucaud, Isabelle
dc.contributor.authorGérard, Christophe-Loïc
dc.contributor.authorvan der Mark, Sanne
dc.contributor.authorSchulz, Enrico
dc.contributor.authorVaessen, Anniek
dc.contributor.authorMaurer, Urs
dc.contributor.authorLohvansuu, Kaisa
dc.contributor.authorLyytinen, Heikki
dc.contributor.authorZucchelli, Marco
dc.contributor.authorBrandeis, Daniel
dc.contributor.authorBlomert, Leo
dc.contributor.authorLeppänen, Paavo Ht
dc.contributor.authorBruder, Jennifer
dc.contributor.authorMonaco, Anthony P
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorKere, Juha
dc.contributor.authorLanderl, Karin
dc.contributor.authorNöthen, Markus M
dc.contributor.authorSchulte-Körne, Gerd
dc.contributor.authorParacchini, Silvia
dc.contributor.authorPeyrard-Janvid, Myriam
dc.contributor.authorSchumacher, Johannes
dc.date.accessioned2015-12-04T10:10:03Z
dc.date.available2015-12-04T10:10:03Z
dc.date.issued2014-05
dc.identifier.citationBecker , J , Czamara , D , Scerri , T S , Ramus , F , Csépe , V , Talcott , J B , Stein , J , Morris , A , Ludwig , K U , Hoffmann , P , Honbolygó , F , Tóth , D , Fauchereau , F , Bogliotti , C , Iannuzzi , S , Chaix , Y , Valdois , S , Billard , C , George , F , Soares-Boucaud , I , Gérard , C-L , van der Mark , S , Schulz , E , Vaessen , A , Maurer , U , Lohvansuu , K , Lyytinen , H , Zucchelli , M , Brandeis , D , Blomert , L , Leppänen , P H , Bruder , J , Monaco , A P , Müller-Myhsok , B , Kere , J , Landerl , K , Nöthen , M M , Schulte-Körne , G , Paracchini , S , Peyrard-Janvid , M & Schumacher , J 2014 , ' Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort ' , European Journal of Human Genetics , vol. 22 , no. 5 , pp. 675-680 . https://doi.org/10.1038/ejhg.2013.199en
dc.identifier.issn1018-4813
dc.identifier.otherPURE: 100721898
dc.identifier.otherPURE UUID: 9686c026-3c78-49b4-8f39-cb250e860cd0
dc.identifier.otherPubMed: 24022301
dc.identifier.otherScopus: 84898824897
dc.identifier.otherORCID: /0000-0001-9934-8602/work/60428108
dc.identifier.otherWOS: 000334600400018
dc.identifier.urihttp://hdl.handle.net/10023/7885
dc.descriptionThe work conducted at the WTCHG was supported by Wellcome Trust grants [076566/Z/05/Z] and [075491/Z/04]; the work in Zurich partly by an SNSF grant [32-108130]. We also thank MAF (Mutation Analysis core Facility) at the Karolinska Institute, Novum, Huddinge. The French part of the project was funded by Agence Nationale de la Recherche (ANR-06-NEURO-019-01 GENEDYS) and Ville de Paris. S Paracchini is a Royal Society University Research Fellow. D Czamara was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation) within the framework of the Munich Cluster for Systems Neurology (EXC 1010 SyNergy).en
dc.description.abstractDyslexia is one of the most common childhood disorders with a prevalence of around 5-10% in school-age children. Although an important genetic component is known to have a role in the aetiology of dyslexia, we are far from understanding the molecular mechanisms leading to the disorder. Several candidate genes have been implicated in dyslexia, including DYX1C1, DCDC2, KIAA0319, and the MRPL19/C2ORF3 locus, each with reports of both positive and no replications. We generated a European cross-linguistic sample of school-age children - the NeuroDys cohort - that includes more than 900 individuals with dyslexia, sampled with homogenous inclusion criteria across eight European countries, and a comparable number of controls. Here, we describe association analysis of the dyslexia candidate genes/locus in the NeuroDys cohort. We performed both case-control and quantitative association analyses of single markers and haplotypes previously reported to be dyslexia-associated. Although we observed association signals in samples from single countries, we did not find any marker or haplotype that was significantly associated with either case-control status or quantitative measurements of word-reading or spelling in the meta-analysis of all eight countries combined. Like in other neurocognitive disorders, our findings underline the need for larger sample sizes to validate possibly weak genetic effects.
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Human Geneticsen
dc.rights© 2014, Macmillan Publishers Ltd. All rights reserved. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.nature.com / https://dx.doi.org/10.1038/ejhg.2013.199en
dc.subjectDyslexiaen
dc.subjectWord-readingen
dc.subjectSpellingen
dc.subjectAssociation studyen
dc.subjectCandidate genesen
dc.subjectQH426 Geneticsen
dc.subjectR Medicineen
dc.subjectBDYen
dc.subject.lccQH426en
dc.subject.lccRen
dc.titleGenetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohorten
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1038/ejhg.2013.199
dc.description.statusPeer revieweden


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