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Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction
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dc.contributor.author | Healy, A. R. | |
dc.contributor.author | Westwood, Nicholas James | |
dc.date.accessioned | 2015-11-17T16:40:02Z | |
dc.date.available | 2015-11-17T16:40:02Z | |
dc.date.issued | 2015-11-14 | |
dc.identifier.citation | Healy , A R & Westwood , N J 2015 , ' Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction ' , Organic & Biomolecular Chemistry , vol. 13 , no. 42 , pp. 10527-10531 . https://doi.org/10.1039/C5OB01771H | en |
dc.identifier.issn | 1477-0520 | |
dc.identifier.other | PURE: 212912791 | |
dc.identifier.other | PURE UUID: b2ff613f-0a80-4202-b448-eb70fba5d072 | |
dc.identifier.other | Scopus: 84946049693 | |
dc.identifier.other | ORCID: /0000-0003-0630-0138/work/56424195 | |
dc.identifier.other | WOS: 000363214100015 | |
dc.identifier.uri | https://hdl.handle.net/10023/7807 | |
dc.description | The authors would like to thank the following for funding: Cancer Research UK (grants C21383/A6950 and C483/A10706) | en |
dc.description.abstract | A late stage Diels-Alder reaction is used to prepare a mixture of JBIR-22, a natural product from the Equisetin family of tetramic acids, and one of its diastereomers. This is achieved in just 8 steps from pyruvate. The success of the late stage DA approach is discussed in the context of the biosynthesis of JBIR-22 (and perhaps related natural products). | |
dc.language.iso | eng | |
dc.relation.ispartof | Organic & Biomolecular Chemistry | en |
dc.rights | Copyright 2015 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.identifier.doi | https://doi.org/10.1039/C5OB01771H | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | http://www.rsc.org/suppdata/c5/ob/c5ob01771h/c5ob01771h1.pdf | en |
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