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Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction

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dc.contributor.authorHealy, A. R.
dc.contributor.authorWestwood, Nicholas James
dc.date.accessioned2015-11-17T16:40:02Z
dc.date.available2015-11-17T16:40:02Z
dc.date.issued2015-11-14
dc.identifier.citationHealy , A R & Westwood , N J 2015 , ' Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction ' , Organic & Biomolecular Chemistry , vol. 13 , no. 42 , pp. 10527-10531 . https://doi.org/10.1039/C5OB01771Hen
dc.identifier.issn1477-0520
dc.identifier.otherPURE: 212912791
dc.identifier.otherPURE UUID: b2ff613f-0a80-4202-b448-eb70fba5d072
dc.identifier.otherScopus: 84946049693
dc.identifier.otherORCID: /0000-0003-0630-0138/work/56424195
dc.identifier.otherWOS: 000363214100015
dc.identifier.urihttps://hdl.handle.net/10023/7807
dc.descriptionThe authors would like to thank the following for funding: Cancer Research UK (grants C21383/A6950 and C483/A10706)en
dc.description.abstractA late stage Diels-Alder reaction is used to prepare a mixture of JBIR-22, a natural product from the Equisetin family of tetramic acids, and one of its diastereomers. This is achieved in just 8 steps from pyruvate. The success of the late stage DA approach is discussed in the context of the biosynthesis of JBIR-22 (and perhaps related natural products).
dc.language.isoeng
dc.relation.ispartofOrganic & Biomolecular Chemistryen
dc.rightsCopyright 2015 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).en
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subject.lccQDen
dc.titleSynthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reactionen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1039/C5OB01771H
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.rsc.org/suppdata/c5/ob/c5ob01771h/c5ob01771h1.pdfen


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