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dc.contributor.authorThompson, Stephen
dc.contributor.authorÓnega, Mayca
dc.contributor.authorAshworth, Sharon
dc.contributor.authorFleming , Ian N.
dc.contributor.authorPasschier , Jan
dc.contributor.authorO'Hagan, David
dc.identifier.citationThompson , S , Ónega , M , Ashworth , S , Fleming , I N , Passchier , J & O'Hagan , D 2015 , ' A two-step fluorinase enzyme mediated 18 F labelling of an RGD peptide for positron emission tomography ' , Chemical Communications , vol. 51 , no. 70 , pp. 13542-13545 .
dc.identifier.otherPURE: 203899096
dc.identifier.otherPURE UUID: fc515502-5526-4906-a17e-77b4f287ae97
dc.identifier.otherScopus: 84939865049
dc.identifier.otherWOS: 000359951200026
dc.identifier.otherORCID: /0000-0002-0510-5552/work/68281279
dc.descriptionThe authors thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.en
dc.description.abstractA two-step radiolabelling protocol of a cancer relevant cRGD peptide is described where the fluorinase enzyme is used to catalyse a transhalogenation reaction to generate [18F]-5'-fluoro-5'-deoxy-2-ethynyladenosine, [18F]FDEA, followed by a ‘click’ reaction to an azide tethered cRGD peptide. This protocol offers an efficient radiolabelling of a biologically relevant peptide construct in water at pH 7.8, 37oC in 2 hours, that was metabolically stable in rats and retained high affinity for the αVβ3 integrin.
dc.relation.ispartofChemical Communicationsen
dc.rightsCopyright 2015 the Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (
dc.subjectQD Chemistryen
dc.titleA two-step fluorinase enzyme mediated 18F labelling of an RGD peptide for positron emission tomographyen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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