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dc.contributor.authorPowathil, Gibin G.
dc.contributor.authorSwat, Maciej
dc.contributor.authorChaplain, Mark A. J.
dc.date.accessioned2015-10-29T13:10:07Z
dc.date.available2015-10-29T13:10:07Z
dc.date.issued2015-02
dc.identifier.citationPowathil , G G , Swat , M & Chaplain , M A J 2015 , ' Systems oncology : towards patient-specific treatment regimes informed by multiscale mathematical modelling ' , Seminars in Cancer Biology , vol. 30 , pp. 13-20 . https://doi.org/10.1016/j.semcancer.2014.02.003en
dc.identifier.issn1044-579X
dc.identifier.otherPURE: 206440203
dc.identifier.otherPURE UUID: 5344ef13-5dc9-4fab-ada9-2e6e37c4c144
dc.identifier.otherRIS: urn:43DD675CB54D50809BED5ECB045BEA54
dc.identifier.otherScopus: 84919636142
dc.identifier.otherORCID: /0000-0001-5727-2160/work/55378855
dc.identifier.urihttp://hdl.handle.net/10023/7713
dc.description.abstractThe multiscale complexity of cancer as a disease necessitates a corresponding multiscale modelling approach to produce truly predictive mathematical models capable of improving existing treatment protocols. To capture all the dynamics of solid tumour growth and its progression, mathematical modellers need to couple biological processes occurring at various spatial and temporal scales (from genes to tissues). Because effectiveness of cancer therapy is considerably affected by intracellular and extracellular heterogeneities as well as by the dynamical changes in the tissue microenvironment, any model attempt to optimise existing protocols must consider these factors ultimately leading to improved multimodal treatment regimes. By improving existing and building new mathematical models of cancer, modellers can play important role in preventing the use of potentially sub-optimal treatment combinations. In this paper, we analyse a multiscale computational mathematical model for cancer growth and spread, incorporating the multiple effects of radiation therapy and chemotherapy in the patient survival probability and implement the model using two different cell based modelling techniques. We show that the insights provided by such multiscale modelling approaches can ultimately help in designing optimal patient-specific multi-modality treatment protocols that may increase patients quality of life.
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofSeminars in Cancer Biologyen
dc.rights© 2015, Publisher / the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at www.sciencedirect.com / https://dx.doi.org/10.1016/j.semcancer.2014.02.003en
dc.subjectHybrid multiscale modelen
dc.subjectCell-cycleen
dc.subjectHypoxiaen
dc.subjectChemotherapyen
dc.subjectRadiation therapyen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectQA Mathematicsen
dc.subjectQH301 Biologyen
dc.subjectNDASen
dc.subject.lccRC0254en
dc.subject.lccQAen
dc.subject.lccQH301en
dc.titleSystems oncology : towards patient-specific treatment regimes informed by multiscale mathematical modellingen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.Applied Mathematicsen
dc.identifier.doihttps://doi.org/10.1016/j.semcancer.2014.02.003
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.sciencedirect.com/science/journal/1044579Xen


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