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Human IFNAR2 deficiency : lessons for antiviral immunity

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Date
30/09/2015
Author
Duncan, Christopher J. A.
Mohamad, Siti M. B.
Young, Dan Frushard
Skelton, Andrew J.
Leahy, T. Ronan
Munday, Diane Carolyn
Butler, Karina M.
Morfopoulou, Sofia
Brown, Julianne R.
Hubank, Mike
Connell, Jeff
Gavin, Patrick J.
McMahon, Cathy
Dempsey, Eugene
Lynch, Niamh E.
Jacques, Thomas S.
Valappil, Manoj
Cant, Andrew J.
Breuer, Judith
Engelhardt, Karin R.
Randall, Richard Edward
Hambleton, Sophie
Funder
The Wellcome Trust
Grant ID
101788/Z/13/Z
Keywords
QH301 Biology
R Medicine
BDC
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Abstract
Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models have been pivotal to understanding the role of IFN-α/β in immunity, although validation of these findings in humans has been limited. We investigated a previously healthy child with fatal encephalitis after inoculation of the live attenuated measles, mumps, and rubella (MMR) vaccine. By targeted resequencing, we identified a homozygous mutation in the high-affinity IFN-α/β receptor (IFNAR2) in the proband, as well as a newborn sibling, that rendered cells unresponsive to IFN-α/β. Reconstitution of the proband's cells with wild-type IFNAR2 restored IFN-α/β responsiveness and control of IFN-attenuated viruses. Despite the severe outcome of systemic live vaccine challenge, the proband had previously shown no evidence of heightened susceptibility to respiratory viral pathogens. The phenotype of IFNAR2 deficiency, together with similar findings in STAT2-deficient patients, supports an essential but narrow role for IFN-α/β in human antiviral immunity.
Citation
Duncan , C J A , Mohamad , S M B , Young , D F , Skelton , A J , Leahy , T R , Munday , D C , Butler , K M , Morfopoulou , S , Brown , J R , Hubank , M , Connell , J , Gavin , P J , McMahon , C , Dempsey , E , Lynch , N E , Jacques , T S , Valappil , M , Cant , A J , Breuer , J , Engelhardt , K R , Randall , R E & Hambleton , S 2015 , ' Human IFNAR2 deficiency : lessons for antiviral immunity ' , Science Translational Medicine , vol. 7 , no. 307 , 307ra154 . https://doi.org/10.1126/scitranslmed.aac4227
Publication
Science Translational Medicine
Status
Peer reviewed
DOI
https://doi.org/10.1126/scitranslmed.aac4227
ISSN
1946-6234
Type
Journal article
Rights
© 2015, Publisher / the Author(s). This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at stm.sciencemag.org / https://dx.doi.org/10.1126/scitranslmed.aac4227
Description
C.J.A.D. was supported by the Academy of Medical Sciences (AMS-SGCL11), the British Infection Association, and the UK NIH Research (NIHR); S.M.B.M. was supported by the Universiti Sains Malaysia Fellowship; K.R.E. and S.H. were supported by the Sir Jules Thorn Trust (12/JTA); D.F.Y., D.C.M., and R.E.R. were supported by the Wellcome Trust (101788/Z/13/Z); and A.J.S. was supported by the Medical Research Council–Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing and NIHR Newcastle Biomedical Research Centre. J.B. receives funding from the UCLH/UCL NIHR Biomedical Research Centre. S.M. is supported by the FP7 PATHSEEK grant. J.R.B. is supported by an NIHR fellowship.
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URI
http://hdl.handle.net/10023/7692

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