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dc.contributor.authorAnderson, Richard A
dc.contributor.authorMitchell, Rod T
dc.contributor.authorKelsey, Thomas W
dc.contributor.authorSpears, Norah
dc.contributor.authorTelfer, Evelyn E
dc.contributor.authorWallace, W Hamish B
dc.identifier.citationAnderson , R A , Mitchell , R T , Kelsey , T W , Spears , N , Telfer , E E & Wallace , W H B 2015 , ' Cancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adults ' , The Lancet Diabetes & Endocrinology , vol. 3 , no. 7 , pp. 556-567 .
dc.identifier.otherPURE: 163911314
dc.identifier.otherPURE UUID: d8a75f3e-7510-4d5d-a58d-78b4589377e2
dc.identifier.otherPubMed: 25873571
dc.identifier.otherScopus: 84934440608
dc.identifier.otherPubMed: 25873571
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201534
dc.identifier.otherWOS: 000357419500031
dc.descriptionCopyright © 2015 Elsevier Ltd. All rights reserved.en
dc.description.abstractPreservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment.. The loss of an opportunity for fertility is a prime concern in both male and female cancer survivors, however the endocrine consequences of gonadal damage are also central to long-term health and wellbeing. Some fertility preservation techniques, such as semen and embryo cryopreservation for the adult man and woman respectively, are established and successful and the recent development of oocyte vitrification has greatly improved the potential to cryopreserve unfertilised oocytes from women. Despite being recommended for all pubertal males, sperm banking is not universally practised in Paediatric Oncology centres, and there are very few ‘adolescent-friendly’ facilities. All approaches to fertility preservation have particular challenges in children and teenagers, including ethical, practical and scientific issues. For the young female, cryopreservation of ovarian cortical tissue with later replacement has now resulted in at least 35 live births, but is still regarded as experimental in most countries. For pre-pubertal males, testicular biopsy cryopreservation is offered in some centres, but it is unclear how that tissue might be used in the future, and to date there is no evidence that fertility can be restored. For both sexes these approaches require an invasive procedure, and there is an uncertain risk of tissue contamination in haematological and other malignancies. Decision making for all these approaches requires an assessment of the individual’s risk of loss of fertility, and is being made at a time of emotional distress. The development of this field requires better provision of information for patients and their medical teams as well as improvements in service provision, to match technical and scientific advances. Search strategy and selection criteria We searched Medline between Jan 1, 1990, and Sept 1, 2014, for reports published in English using the search terms “fertility preservation”, “cancer”, “childhood cancer”, “gonadotoxic”, and “cancer treatment” in several disjunctive and conjunctive combinations. We mainly selected publications in English from the past 5 years, but did not exclude older, significant publications. We also checked the reference lists of articles identified by this search strategy.
dc.relation.ispartofThe Lancet Diabetes & Endocrinologyen
dc.rightsCopyright © 2015 Elsevier Ltd. All rights reserved. All rights reserved. This is the author’s version of a work that was accepted for publication in The Lancet Diabetes & Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The Lancet Diabetes & Endocrinology, [Vol], 12 April 2015 DOI 10.1016/S2213-8587(15)00039-Xen
dc.subjectFertility Preservationen
dc.subjectRisk Factorsen
dc.subjectYoung Adulten
dc.subjectJournal Articleen
dc.subjectQA75 Electronic computers. Computer scienceen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleCancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adultsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Interdisciplinary Research in Computational Algebraen
dc.description.statusPeer revieweden

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