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dc.contributor.authorSchluter, Daniela K.
dc.contributor.authorRamis-Conde, Ignacio
dc.contributor.authorChaplain, Mark A. J.
dc.identifier.citationSchluter , D K , Ramis-Conde , I & Chaplain , M A J 2015 , ' Multi-scale modelling of the dynamics of cell colonies : insights into cell-adhesion forces and cancer invasion from in silico simulations ' , Journal of the Royal Society Interface , vol. 12 , no. 103 , 20141080 , pp. 1-13 .
dc.identifier.otherPURE: 206436327
dc.identifier.otherPURE UUID: 50dc08d0-98d5-4964-9bee-c38e229b8634
dc.identifier.otherRIS: urn:481794096B9C3F38BBF9E21F4DA52F11
dc.identifier.otherScopus: 85005790455
dc.identifier.otherORCID: /0000-0001-5727-2160/work/55378916
dc.description.abstractStudying the biophysical interactions between cells is crucial to understanding how normal tissue develops, how it is structured and also when malfunctions occur. Traditional experiments try to infer events at the tissue level after observing the behaviour of and interactions between individual cells. This approach assumes that cells behave in the same biophysical manner in isolated experiments as they do within colonies and tissues. In this paper, we develop a multi-scale multi-compartment mathematical model that accounts for the principal biophysical interactions and adhesion pathways not only at a cell-cell level but also at the level of cell colonies (in contrast to the traditional approach). Our results suggest that adhesion/separation forces between cells may be lower in cell colonies than traditional isolated single-cell experiments infer. As a consequence, isolated single-cell experiments may be insufficient to deduce important biological processes such as single-cell invasion after detachment from a solid tumour. The simulations further show that kinetic rates and cell biophysical characteristics such as pressure-related cell-cycle arrest have a major influence on cell colony patterns and can allow for the development of protrusive cellular structures as seen in invasive cancer cell lines independent of expression levels of pro-invasion molecules.
dc.relation.ispartofJournal of the Royal Society Interfaceen
dc.rightsCopyright 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License, which permits unrestricted use, provided the original author and source are credited.en
dc.subjectIndividual-based modellingen
dc.subjectCell population modellingen
dc.subjectCell-adhesion forcesen
dc.subjectQA75 Electronic computers. Computer scienceen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleMulti-scale modelling of the dynamics of cell colonies : insights into cell-adhesion forces and cancer invasion from in silico simulationsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Applied Mathematicsen
dc.description.statusPeer revieweden

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