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dc.contributor.authorDewailly, Didier
dc.contributor.authorAndersen, Claus Yding
dc.contributor.authorBalen, Adam
dc.contributor.authorBroekmans, Frank
dc.contributor.authorDilaver, Nafi
dc.contributor.authorFanchin, Renato
dc.contributor.authorGriesinger, Georg
dc.contributor.authorKelsey, Tom W
dc.contributor.authorLa Marca, Antonio
dc.contributor.authorLambalk, Cornelius
dc.contributor.authorMason, Helen
dc.contributor.authorNelson, Scott M
dc.contributor.authorVisser, Jenny A
dc.contributor.authorWallace, W Hamish
dc.contributor.authorAnderson, Richard A
dc.date.accessioned2015-09-16T14:40:01Z
dc.date.available2015-09-16T14:40:01Z
dc.date.issued2014
dc.identifier.citationDewailly , D , Andersen , C Y , Balen , A , Broekmans , F , Dilaver , N , Fanchin , R , Griesinger , G , Kelsey , T W , La Marca , A , Lambalk , C , Mason , H , Nelson , S M , Visser , J A , Wallace , W H & Anderson , R A 2014 , ' The physiology and clinical utility of anti-Müllerian hormone in women ' , Human Reproduction Update , vol. 20 , no. 3 , pp. 370-385 . https://doi.org/10.1093/humupd/dmt062en
dc.identifier.issn1460-2369
dc.identifier.otherPURE: 106776730
dc.identifier.otherPURE UUID: 7bf90b2e-914b-48c6-b6fc-a7bed0e52b0c
dc.identifier.otherPubMed: 24430863
dc.identifier.otherScopus: 84896987631
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201545
dc.identifier.otherWOS: 000334675600004
dc.identifier.urihttps://hdl.handle.net/10023/7488
dc.descriptionThis paper is a summary of the presentations at the ESHRE campus workshop on AMH in Lille, France, on 10–11 May 2012, with literature update until September 2013. We are grateful to Ronnie Grant for assistance with the figures.en
dc.description.abstractBACKGROUND The measurement of circulating anti-Müllerian hormone (AMH) has been applied to a wide array of clinical applications, mainly based on its ability to reflect the number of antral and pre-antral follicles present in the ovaries. AMH has been suggested to predict the ovarian response to hyperstimulation of the ovaries for IVF and the timing of menopause, and to indicate iatrogenic damage to the ovarian follicle reserve. It has also been proposed as a surrogate for antral follicle count (AFC) in the diagnosis of polycystic ovary syndrome (PCOS). METHODS This paper is a summary of presentations at a European Society of Human Reproduction and Embryology campus workshop on AMH, with literature cited until September 2013. Published peer-reviewed medical literature about AMH was searched through MEDLINE and was subjected to systematic review and critical assessment by the panel of authors. RESULTS Physiologically, recent data confirm that AMH is a follicular gatekeeper limiting follicle growth initiation, and subsequently estradiol production from small antral follicles prior to selection. AMH assays continue to evolve and technical issues remain; the absence of an international standard is a key issue. The dynamics of circulating AMH levels throughout life can be split into several distinct phases, with a peak in the early 20s before a decline to the menopause, with a strong and positive correlation with non-growing follicle recruitment. There is a more complex rise during childhood and adolescence, which is likely to be more reflective of different stages of follicle development. AMH shows limited short-term variability, but the influence of states such as prolonged oral contraceptive use need to be considered in clinical assessment. There are only very limited data on relationships between AMH and natural fertility at different stages of reproductive life, and while it has a relationship to age at menopause the marked variability in this needs further exploration. AMH may be useful in assessing the need for fertility preservation strategies and detecting post-chemotherapy or surgical damage to the ovarian reserve. Long-term follow-up of patients to ascertain fully the value of post-cancer serum AMH in predicting long-term ovarian function is required. There is a linear relationship between AMH and oocyte yield after ovarian stimulation, which is of value in predicting ovarian hyperstimulation. AMH can also identify 'poor responders', but it seems inappropriate at present to withhold IVF purely on this basis. Women with PCOS show markedly raised AMH levels, due to both the increased number of small antral follicles and intrinsic characteristics of those granulosa cells, and this may contribute to anovulation. The value of AMH in the diagnosis of PCOS remains controversial, but it may replace AFC in the future. CONCLUSIONS For the first time in female reproductive biology, it is possible to measure the submerged part of the iceberg of follicle growth, i.e. the intrinsic, so-called 'acyclic' ovarian activity. An international standard for AMH and improved assay validity are urgently needed to maximize the clinical utility of this very promising biomarker of ovarian function in a large array of clinical situations, both in childhood and adulthood.
dc.language.isoeng
dc.relation.ispartofHuman Reproduction Updateen
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Reproduction Update following peer review. The definitive publisher-authenticated version The physiology and clinical utility of anti-Müllerian hormone in women Dewailly, D., Andersen, C. Y., Balen, A., Broekmans, F., Dilaver, N., Fanchin, R., Griesinger, G., Kelsey, T. W., La Marca, A., Lambalk, C., Mason, H., Nelson, S. M., Visser, J. A., Wallace, W. H. & Anderson, R. A. 2014 In : Human Reproduction Update. 20, 3, p. 370-385 is available online at: http://humupd.oxfordjournals.org/content/20/3/370en
dc.subjectanti-Müllerian hormoneen
dc.subjectFollicle growthen
dc.subjectOvarian reserveen
dc.subjectAssayen
dc.subjectAntral follicle counten
dc.subjectQP Physiologyen
dc.subjectRC Internal medicineen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccQPen
dc.subject.lccRCen
dc.titleThe physiology and clinical utility of anti-Müllerian hormone in womenen
dc.typeJournal articleen
dc.contributor.sponsorEPSRCen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews. School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews. Centre for Interdisciplinary Research in Computational Algebraen
dc.identifier.doihttps://doi.org/10.1093/humupd/dmt062
dc.description.statusPeer revieweden
dc.identifier.urlhttp://humupd.oxfordjournals.org/content/20/3/370.fullen
dc.identifier.grantnumberEP/H004092/1en


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