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dc.contributor.authorBertrand, Stéphanie
dc.contributor.authorAldea, Daniel
dc.contributor.authorOulion, Silvan
dc.contributor.authorSubirana, Lucie
dc.contributor.authorde Lera, Angel R.
dc.contributor.authorSomorjai, Ildiko Maureen Lara
dc.contributor.authorEscriva, Hector
dc.date.accessioned2015-09-16T10:40:05Z
dc.date.available2015-09-16T10:40:05Z
dc.date.issued2015-09-15
dc.identifier.citationBertrand , S , Aldea , D , Oulion , S , Subirana , L , de Lera , A R , Somorjai , I M L & Escriva , H 2015 , ' Evolution of the role of RA and FGF signals in the control of somitogenesis in chordates ' , PLoS One , vol. 10 , no. 9 , e0136587 . https://doi.org/10.1371/journal.pone.0136587en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 215233954
dc.identifier.otherPURE UUID: 1f27b805-4a11-4786-b62c-a20f8af86480
dc.identifier.otherScopus: 84945945586
dc.identifier.otherORCID: /0000-0001-5243-6664/work/46168667
dc.identifier.urihttps://hdl.handle.net/10023/7483
dc.descriptionThe laboratory of HE is supported by the ANR BLAN 1716 01. IMLS´s laboratory is currently supported by MASTS (Marine Alliance for Science and Technology Scotland).en
dc.description.abstractDuring vertebrate development, the paraxial mesoderm becomes segmented, forming somites that will give rise to dermis, axial skeleton and skeletal muscles. Although recently challenged, the "clock and wavefront" model for somitogenesis explains how interactions between several cell-cell communication pathways, including the FGF, RA, Wnt and Notch signals, control the formation of these bilateral symmetric blocks. In the cephalochordate amphioxus, which belongs to the chordate phylum together with tunicates and vertebrates, the dorsal paraxial mesendoderm also periodically forms somites, although this process is asymmetric and extends along the whole body. It has been previously shown that the formation of the most anterior somites in amphioxus is dependent upon FGF signalling. However, the signals controlling somitogenesis during posterior elongation in amphioxus are still unknown. Here we show that, contrary to vertebrates, RA and FGF signals act independently during posterior elongation and that they are not mandatory for posterior somites to form. Moreover, we show that RA is not able to buffer the left/right asymmetry machinery that is controlled through the asymmetric expression of Nodal pathway actors. Our results give new insights into the evolution of the somitogenesis process in chordates. They suggest that RA and FGF pathways have acquired specific functions in the control of somitogenesis in vertebrates. We propose that the "clock and wavefront" system was selected specifically in vertebrates in parallel to the development of more complex somite-derived 45 structures but that it was not required for somitogenesis in the ancestor of chordates.
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.rights© 2015 Bertrand et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectSomitogenesisen
dc.subjectL/R asymmetryen
dc.subjectAmphioxusen
dc.subjectEvo-Devoen
dc.subjectRetinoic aciden
dc.subjectFibroblast growth factoren
dc.subjectQH301 Biologyen
dc.subject.lccQH301en
dc.titleEvolution of the role of RA and FGF signals in the control of somitogenesis in chordatesen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews. Scottish Oceans Instituteen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0136587
dc.description.statusPeer revieweden


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