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dc.contributor.authorLaabei, Maisem
dc.contributor.authorUhlemann, Anne-Catrin
dc.contributor.authorLowy, Franklin D
dc.contributor.authorAustin, Eloise D
dc.contributor.authorYokoyama, Maho
dc.contributor.authorOuadi, Khadija
dc.contributor.authorFeil, Edward
dc.contributor.authorThorpe, Harry A
dc.contributor.authorWilliams, Barnabas
dc.contributor.authorPerkins, Mark
dc.contributor.authorPeacock, Sharon J
dc.contributor.authorClarke, Stephen R
dc.contributor.authorDordel, Janina
dc.contributor.authorHolden, Matthew
dc.contributor.authorVotintseva, Antonina A
dc.contributor.authorBowden, Rory
dc.contributor.authorCrook, Derrick W
dc.contributor.authorYoung, Bernadette C
dc.contributor.authorWilson, Daniel J
dc.contributor.authorRecker, Mario
dc.contributor.authorMassey, Ruth C
dc.identifier.citationLaabei , M , Uhlemann , A-C , Lowy , F D , Austin , E D , Yokoyama , M , Ouadi , K , Feil , E , Thorpe , H A , Williams , B , Perkins , M , Peacock , S J , Clarke , S R , Dordel , J , Holden , M , Votintseva , A A , Bowden , R , Crook , D W , Young , B C , Wilson , D J , Recker , M & Massey , R C 2015 , ' Evolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureus ' , PLoS Biology , vol. 13 , no. 9 , e1002229 .
dc.identifier.otherPURE: 214495861
dc.identifier.otherPURE UUID: c7b7c54e-a31d-47aa-8a88-7b2a372ffc42
dc.identifier.otherPubMed: 26331877
dc.identifier.otherScopus: 84943144528
dc.identifier.otherORCID: /0000-0002-4958-2166/work/60196385
dc.identifier.otherWOS: 000362266100001
dc.descriptionDate of Acceptance: 20/07/2015en
dc.description.abstractBacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and is widely accepted as playing a crucial role in disease pathology. To understand the relationship between toxicity and bacterial virulence in greater depth, we studied two sequenced collections of the major human pathogen Staphylococcus aureus and found an unexpected inverse correlation between bacterial toxicity and disease severity. By applying a functional genomics approach, we identified several novel toxicity-affecting loci responsible for the wide range in toxic phenotypes observed within these collections. To understand the apparent higher propensity of low toxicity isolates to cause bacteraemia, we performed several functional assays, and our findings suggest that within-host fitness differences between high- and low-toxicity isolates in human serum is a contributing factor. As invasive infections, such as bacteraemia, limit the opportunities for onward transmission, highly toxic strains could gain an additional between-host fitness advantage, potentially contributing to the maintenance of toxicity at the population level. Our results clearly demonstrate how evolutionary trade-offs between toxicity, relative fitness, and transmissibility are critical for understanding the multifaceted nature of bacterial virulence.
dc.relation.ispartofPLoS Biologyen
dc.rightsCopyright: © 2015 Laabei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectR Medicineen
dc.subjectQR Microbiologyen
dc.titleEvolutionary trade-offs underlie the multi-faceted virulence of Staphylococcus aureusen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Infection Groupen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.description.statusPeer revieweden

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