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dc.contributor.authorMwalukomo, Thandie
dc.contributor.authorRylance, Sarah
dc.contributor.authorWebb, Emily
dc.contributor.authorAnderson, Suzanne
dc.contributor.authorO'Hare, Bernadette Ann-Marie
dc.contributor.authorvan Oosterhout, Joep J.
dc.contributor.authorFerrand, Rashida A.
dc.contributor.authorCorbett, Elizabeth L.
dc.contributor.authorRylance, Jamie
dc.identifier.citationMwalukomo , T , Rylance , S , Webb , E , Anderson , S , O'Hare , B A-M , van Oosterhout , J J , Ferrand , R A , Corbett , E L & Rylance , J 2016 , ' Clinical characteristics and lung function in older children vertically infected with Human Immunodeficiency Virus in Malawi ' , Journal of the Pediatric Infectious Diseases Society , vol. 5 , no. 2 , pp. 161-169 .
dc.identifier.otherPURE: 212751696
dc.identifier.otherPURE UUID: 7737d0d1-8c19-4d66-826f-7434880ee3fd
dc.identifier.otherScopus: 85006218741
dc.identifier.otherORCID: /0000-0003-1730-7941/work/27345651
dc.identifier.otherWOS: 000386134800012
dc.descriptionT. M. was funded by the Commonwealth scholarship, with research costs from a grant fom Helse Nord Northern Norway Regional Health Authority. E. L. C., R. A. F., and J. R. are supported by Wellcome Trust Fellowships (Senior Fellowship in Clinical Sciences WT091769, Career Development Fellowship WT095878 and Clinical PhD Fellowship 086756/B/08/Z, respectively).en
dc.description.abstractBackground Antiretroviral therapy (ART) has led to increased survival of children with vertically acquired human immunodeficiency virus infection. Significant morbidity arises from respiratory symptoms, but aetiology and pulmonary function abnormalities have not been systematically studied. Methods Human immunodeficiency virus-positive children aged 8–16 years were systematically recruited within clinics in Blantyre, Malawi. Clinical review, quality of life assessment, spirometry, and chest radiography were performed. Results One hundred sixty participants had a mean of age 11.1 (range, 8–16) years and 50.0% were female. Cough was present in 60 (37.5%) participants, and 55 (34.4%) had moderate or severe dyspnoea. Thirty-four (22.1%) participants had digital clubbing. Thirty-three (20.6%) participants were hypoxic at rest. One hundred eighteen (73.8%) of the children were receiving ART; median CD4 count was 698 cells/µL in these compared with 406 cells/µL in ART-naive individuals (P < .001). From 145 spirometry traces (90.6%), mean forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were 1.06 and 0.89 standard deviations below predicted mean, respectively. Twenty-one (14.5%) traces demonstrated obstructive defects and 26 (17.9%) reduced FVC. Lung function abnormality was not associated with any clinical findings. Of the 51 individuals with abnormal lung function, the mean increase in FEV1 after salbutamol was 3.8% (95% confidence interval, 0.02–7.53). “Tramlines” and ring shadows were seen on chest radiographs in over half of cases. Conclusions Symptoms of chronic lung disease were highly prevalent with 2 main clinical phenotypes: “cough” and “hypoxia”. Lung function abnormalities are common, poorly responsive to bronchodilators, and apparent throughout the age range of our cohort. Pathological causes remain to be elucidated. Cough and hypoxic phenotypes could be a useful part of diagnostic algorithms if further validated.
dc.relation.ispartofJournal of the Pediatric Infectious Diseases Societyen
dc.rights© The Author 2015. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectCase definitionen
dc.subjectChronic lung diseaseen
dc.subjectInfectious disease transmissionen
dc.subjectRespiratory function testsen
dc.subjectRJ101 Child Health. Child health servicesen
dc.titleClinical characteristics and lung function in older children vertically infected with Human Immunodeficiency Virus in Malawien
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Global Health Implementation Groupen
dc.description.statusPeer revieweden

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