3D Monte Carlo radiation transfer modelling of photodynamic therapy
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The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.
Campbell , C L , Christison , C , Brown , C T A , Wood , K , Valentine , R M & Moseley , H 2015 , 3D Monte Carlo radiation transfer modelling of photodynamic therapy . in C Kurachi , K Svanberg , B J Tromberg & V S Bagnato (eds) , Biophotonics South America . Proceedings of SPIE , vol. 9531 , SPIE , Biophotonics South America , Rio de Janeiro , Brazil , 23/05/15 . https://doi.org/10.1117/12.2180744conference
Biophotonics South America
Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Originally published by SPIE here: http://dx.doi.org/10.1117/12.2180744
DescriptionWe acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell as well as the Alfred Stewart Trust.
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