Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes
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Feasibility studies are needed to demonstrate that safe and effective manipulation of bowel during Minimal Access Surgery (MAS) can be obtained by use of magnetic force. This paper characterises two classes of magnetic particles: stainless steel microparticles (SS-μPs) and iron oxide nanoparticles (IO-nPs) in terms of their magnetisation, chemical composition, crystallinity, morphology and size distribution. Both magnetic particles were dispersed in a high viscosity biological liquid for intraluminal injection of bowel. Ex vivo porcine bowel segments were then retracted by permanent magnetic probes of 5.0 and 10 mm diameter. Strong retraction forces reaching 6 N maximum were obtained by magnetic fluid based on dispersion of SS-μPs. In contrast, the IO-nP-based magnetic liquid generated less attraction force, due to both lower magnetic and solution properties of the IO-nPs. The comparison of the two particles allowed the identification of the rules to engineer the next generation of particles. The results with SS-μPs provide proof on concept that intraluminal injection of magnetic fluid can generate sufficient force for efficient bowel retraction. Thereafter we shall carry out in vivo animal studies for efficacy and safety of both types of ferrofluids.
Wang , Z , André , P , McLean , D , Brown , S I , Florence , G J & Cuschieri , A 2014 , ' Intraluminal magnetisation of bowel by ferromagnetic particles for retraction and manipulation by magnetic probes ' Medical Engineering and Physics , vol 36 , no. 11 , pp. 1521-1525 . DOI: 10.1016/j.medengphy.2014.07.013
Medical Engineering and Physics
NOTICE: this is the author’s version of a work that was accepted for publication in Medical Engineering & Physics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Medical Engineering & Physics, 36(11), 2014. doi:10.1016/j.medengphy.2014.07.013
DescriptionThis work has been financially supported by the Engineering and Physical Sciences Research Council (EPSRC), UK, under Grant EP/HO 10033/1.
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