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dc.contributor.authorBrown, Gillian R.
dc.contributor.authorKulbarsh, Kyle D.
dc.contributor.authorSpencer, Karen A.
dc.contributor.authorDuval, Camille
dc.identifier.citationBrown , G R , Kulbarsh , K D , Spencer , K A & Duval , C 2015 , ' Peri-pubertal exposure to testicular hormones organizes response to novel environments and social behaviour in adult male rats ' , Hormones and Behavior , vol. 73 , pp. 135–141 .
dc.identifier.otherPURE: 199783314
dc.identifier.otherPURE UUID: b19a8cdd-3136-42c5-ae12-c3b3d0692d0a
dc.identifier.otherScopus: 84937912725
dc.identifier.otherORCID: /0000-0002-0675-0780/work/60195746
dc.identifier.otherWOS: 000360251800017
dc.identifier.otherORCID: /0000-0002-2851-9379/work/78204984
dc.descriptionFunding was received from the Wellcome Trust ISSF (grant ID 097831/Z/11/Z) scheme, awarded to the University of St Andrews.en
dc.description.abstractPrevious research has shown that exposure to testicular hormones during the peri-pubertal period of life has long-term, organizational effects on adult sexual behaviour and underlying neural mechanisms in laboratory rodents. However, the organizational effects of peri-pubertal testicular hormones on other aspects of behaviour and brain function are less well understood. Here, we investigated the effects of manipulating peri-pubertal testicular hormone exposure on later behavioural responses to novel environments and on hormone receptors in various brain regions that are involved in response to novelty. Male rodents generally spend less time in the exposed areas of novel environments than females, and this sex difference emerges during the peri-pubertal period. Male Lister-hooded rats (Rattus norvegicus) were castrated either before puberty or after puberty, then tested in three novel environments (elevated plus-maze, light–dark box, open field) and in an object/social novelty task in adulthood. Androgen receptor (AR), oestrogen receptor (ER1) and corticotropin-releasing factor receptor (CRF-R2) mRNA expression were quantified in the hypothalamus, hippocampus and medial amygdala. The results showed that pre-pubertally castrated males spent more time in the exposed areas of the elevated-plus maze and light–dark box than post-pubertally castrated males, and also confirmed that peri-pubertal hormone exposure influences later response to an opposite-sex conspecific. Hormone receptor gene expression levels did not differ between pre-pubertally and post-pubertally castrated males in any of the brain regions examined. This study therefore demonstrates that testicular hormone exposure during the peri-pubertal period masculinizes later response to novel environments, although the neural mechanisms remain to be fully elucidated.
dc.relation.ispartofHormones and Behavioren
dc.rightsCopyright © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (
dc.subjectSex differencesen
dc.subjectSexual behavioren
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titlePeri-pubertal exposure to testicular hormones organizes response to novel environments and social behaviour in adult male ratsen
dc.typeJournal articleen
dc.contributor.sponsorThe Wellcome Trusten
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. Centre for Social Learning & Cognitive Evolutionen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.description.statusPeer revieweden

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