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dc.contributor.authorCotton, James A.
dc.contributor.authorLilley, Catherine J.
dc.contributor.authorJones, Laura M.
dc.contributor.authorKikuchi, Taisei
dc.contributor.authorReid, Adam J.
dc.contributor.authorThorpe, Peter
dc.contributor.authorTsai, Isheng J.
dc.contributor.authorBeasley, Helen
dc.contributor.authorBlok, Vivian
dc.contributor.authorCock, Peter J. A.
dc.contributor.authorEves-van den Akker, Sebastian
dc.contributor.authorHolroyd, Nancy
dc.contributor.authorHunt, Martin
dc.contributor.authorMantelin, Sophie
dc.contributor.authorNaghra, Hardeep
dc.contributor.authorPain, Arnab
dc.contributor.authorPalomares-Rius, Juan E.
dc.contributor.authorZarowiecki, Magdalena
dc.contributor.authorBerriman, Matthew
dc.contributor.authorJones, John T.
dc.contributor.authorUrwin, Peter E.
dc.identifier.citationCotton , J A , Lilley , C J , Jones , L M , Kikuchi , T , Reid , A J , Thorpe , P , Tsai , I J , Beasley , H , Blok , V , Cock , P J A , Eves-van den Akker , S , Holroyd , N , Hunt , M , Mantelin , S , Naghra , H , Pain , A , Palomares-Rius , J E , Zarowiecki , M , Berriman , M , Jones , J T & Urwin , P E 2014 , ' The genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematode ' , Genome Biology , vol. 15 , R43 .
dc.identifier.otherPURE: 208028097
dc.identifier.otherPURE UUID: fceea2bf-de65-47bf-a326-1912b19ed8aa
dc.identifier.otherWOS: 000338981300004
dc.identifier.otherScopus: 84897947420
dc.identifier.otherPubMed: 24580726
dc.identifier.otherPubMedCentral: PMC4054857
dc.description.abstractBackground: Globodera pallida is a devastating pathogen of potato crops, making it one of the most economically important plant parasitic nematodes. It is also an important model for the biology of cyst nematodes. Cyst nematodes and root-knot nematodes are the two most important plant parasitic nematode groups and together represent a global threat to food security. Results: We present the complete genome sequence of G. pallida, together with transcriptomic data from most of the nematode life cycle, particularly focusing on the life cycle stages involved in root invasion and establishment of the biotrophic feeding site. Despite the relatively close phylogenetic relationship with root-knot nematodes, we describe a very different gene family content between the two groups and in particular extensive differences in the repertoire of effectors, including an enormous expansion of the SPRY domain protein family in G. pallida, which includes the SPRYSEC family of effectors. This highlights the distinct biology of cyst nematodes compared to the root-knot nematodes that were, until now, the only sedentary plant parasitic nematodes for which genome information was available. We also present in-depth descriptions of the repertoires of other genes likely to be important in understanding the unique biology of cyst nematodes and of potential drug targets and other targets for their control. Conclusions: The data and analyses we present will be central in exploiting post-genomic approaches in the development of much-needed novel strategies for the control of G. pallida and related pathogens.
dc.relation.ispartofGenome Biologyen
dc.rightsCopyright © 2014 Cotton et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectNematode speciesen
dc.subjectCyst nematodeen
dc.subjectPlant parasitic nematodeen
dc.subjectParasitic stageen
dc.subjectRNAi pathwayen
dc.subjectQH301 Biologyen
dc.titleThe genome and life-stage specific transcriptomes of Globodera pallida elucidate key aspects of plant parasitism by a cyst nematodeen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.description.statusPeer revieweden

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