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dc.contributor.authorSingh, Abhishek
dc.contributor.authorPallikadavath, Saseendran
dc.contributor.authorOgollah, Reuben
dc.contributor.authorStones, William
dc.date.accessioned2015-06-30T15:10:01Z
dc.date.available2015-06-30T15:10:01Z
dc.date.issued2012-11-09
dc.identifier.citationSingh , A , Pallikadavath , S , Ogollah , R & Stones , W 2012 , ' Maternal tetanus toxoid vaccination and neonatal mortality in rural North India ' , PLoS One , vol. 7 , no. 11 , 48891 . https://doi.org/10.1371/journal.pone.0048891en
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 153951139
dc.identifier.otherPURE UUID: 7f3e8cd4-799a-41fa-bc1f-0d4ecdfc095c
dc.identifier.otherWOS: 000312272600024
dc.identifier.otherScopus: 84869049942
dc.identifier.urihttp://hdl.handle.net/10023/6881
dc.description.abstractObjectives: Preventable neonatal mortality due to tetanus infection remains common. We aimed to examine antenatal vaccination impact in a context of continuing high neonatal mortality in rural northern India. Methods and Findings: Using the third round of the Indian National Family Health Survey (NFHS) 2005-06, mortality of most recent singleton births was analysed in discrete-time logistic model with maternal tetanus vaccination, together with antenatal care utilisation and supplementation with iron and folic acid. 59% of mothers reported receiving antenatal care, 48% reported receiving iron and folic acid supplementation and 68% reported receiving two or more doses of tetanus toxoid (TT) vaccination. The odds of all-cause neonatal death were reduced following one or more antenatal dose of TT with odds ratios (OR) of 0.46 (95% CI 0.26 to 0.78) after one dose and 0.45 (95% CI 0.31 to 0.66) after two or more doses. Reported utilisation of antenatal care and iron-folic acid supplementation did not influence neonatal mortality. In the statistical model, 16% (95% CI 5% to 27%) of neonatal deaths could be attributed to a lack of at least two doses of TT vaccination during pregnancy, representing an estimated 78,632 neonatal deaths in absolute terms. Conclusions: Substantial gains in newborn survival could be achieved in rural North India through increased coverage of antenatal TT vaccination. The apparent substantial protective effect of a single antenatal dose of TT requires further study. It may reflect greater population vaccination coverage and indicates that health programming should prioritise universal antenatal coverage with at least one dose. Citation: Singh A, Pallikadavath S, Ogollah R, Stones W (2012) Maternal Tetanus Toxoid Vaccination and Neonatal Mortality in Rural North India. PLoS ONE 7(11): e48891. doi: 10.1371/journal.pone.0048891
dc.format.extent7
dc.language.isoeng
dc.relation.ispartofPLoS Oneen
dc.rights© 2012 Singh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectAntenatal careen
dc.subjectChild-mortalityen
dc.subjectUttar-Pradeshen
dc.subjectHealthen
dc.subjectInterventionsen
dc.subjectImmunizationen
dc.subjectDeathsen
dc.subjectBangladeshen
dc.subjectDurationen
dc.subjectImpacten
dc.subjectRA0421 Public health. Hygiene. Preventive Medicineen
dc.subject.lccRA0421en
dc.titleMaternal tetanus toxoid vaccination and neonatal mortality in rural North Indiaen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Global Health Implementation Groupen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0048891
dc.description.statusPeer revieweden


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