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An externally validated age-related model of mean follicle density in the cortex of the human ovary

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Date
07/2015
Author
McLaughlin, Marie
Kelsey, Tom
Wallace, W Hamish B
Anderson, Richard A
Telfer, Evelyn E
Keywords
Adolescent
Adult
Aging
Female
Humans
Models, Biological
Ovarian Follicle
Ovary
Reproducibility of Results
Young Adult
Journal Article
Research Support, Non-U.S. Gov't
QA75 Electronic computers. Computer science
R Medicine
NDAS
Metadata
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Abstract
The population of non-growing follicles present in the ovary is defined as the ovarian reserve. This underpins the reproductive lifespan in women, with its depletion determining age at loss of fertility and the menopause. Data amassed from published results of indirect invasive and non-invasive procedures has resulted in the generation of predictive models which estimate the ovarian reserve from conception throughout adult life. The distribution of follicles in the ovary is not uniform, with the great majority of NGFs located in the cortex, which is the region normally biopsied and used for fertility preservation. Previous models have however analysed whole ovary NGF populations and ovarian volumes, but not cortical NGF density. In this study we compared mean non-growing follicle density values obtained from tissue samples from 13 ovarian cortical biopsies (16-37 years) against age- matched model-predicted values generated from population and ovarian volume models, taking into account the proportion of the ovary that is cortex. A mean non-growing follicle density was calculated for each patient by counting all follicles in a given volume of freshly biopsied ovarian cortical tissue. These values were compared to age-matched model generated densities and the correlation between data sets tested. Non-growing follicle density values obtained from fresh biopsied ovarian cortex samples closely matched model generated data with low mean difference, tight agreement limits and no proportional error between the observed and predicted results. These findings validate the use of the population and ovarian volume models to accurately predict mean follicle density in the ovarian cortex of adult women.
Citation
McLaughlin , M , Kelsey , T , Wallace , W H B , Anderson , R A & Telfer , E E 2015 , ' An externally validated age-related model of mean follicle density in the cortex of the human ovary ' , Journal of Assisted Reproduction and Genetics , vol. 32 , no. 7 , pp. 1089-1095 . https://doi.org/10.1007/s10815-015-0501-7
Publication
Journal of Assisted Reproduction and Genetics
Status
Peer reviewed
DOI
https://doi.org/10.1007/s10815-015-0501-7
ISSN
1058-0468
Type
Journal article
Rights
This article is published with open access at Springerlink.com (c) The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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  • University of St Andrews Research
URL
http://link.springer.com/article/10.1007/s10815-015-0501-7/fulltext.html
URI
http://hdl.handle.net/10023/6772

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