Gold(I)-catalysed dehydrative formation of ethers from benzylic alcohols and phenols
MetadataShow full item record
We report the cross-dehydrative reaction of two alcohols to form unsymmetrical ethers using NHC-gold(I) complexes (NHC = N-heterocylic carbene). The optimised methodology proceeds under mild reaction conditions and produces water as the sole by-product. The synthetic utility of this environmentally benign methodology is exemplified by forming a range of ethers from readily available phenols bearing electron-withdrawing substituents and secondary benzylic alcohols with various substituents. Finally, the chemoselectivity obtained in these reactions is explained.
Veenboer , R M P & Nolan , S P 2015 , ' Gold(I)-catalysed dehydrative formation of ethers from benzylic alcohols and phenols ' Green Chemistry , vol 17 , no. 7 , pp. 3819-3825 . DOI: 10.1039/C5GC00684H
Copyright 2015 the Authors. This open access article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
DescriptionThe EPSRC and ERC are gratefully acknowledged for support. S.P.N. is a Royal Society Wolfson Research Merit Award holder.
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.