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The relation between variation in size of the primordial follicle pool and age at natural menopause
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dc.contributor.author | Depmann, M | |
dc.contributor.author | Faddy, M J | |
dc.contributor.author | van der Schoew, Y T | |
dc.contributor.author | Peeters, P H M | |
dc.contributor.author | Broer, S L | |
dc.contributor.author | Kelsey, Tom | |
dc.contributor.author | Nelson, S M | |
dc.contributor.author | Broekmans, F J M | |
dc.date.accessioned | 2015-04-28T15:01:01Z | |
dc.date.available | 2015-04-28T15:01:01Z | |
dc.date.issued | 2015-06 | |
dc.identifier.citation | Depmann , M , Faddy , M J , van der Schoew , Y T , Peeters , P H M , Broer , S L , Kelsey , T , Nelson , S M & Broekmans , F J M 2015 , ' The relation between variation in size of the primordial follicle pool and age at natural menopause ' , Journal of Clinical Endocrinology & Metabolism , vol. 100 , no. 6 , pp. E852-E860 . https://doi.org/10.1210/jc.2015-1298 | en |
dc.identifier.issn | 0021-972X | |
dc.identifier.other | PURE: 183861720 | |
dc.identifier.other | PURE UUID: a2a8e0a5-3f90-425e-ae87-8c70199b6284 | |
dc.identifier.other | PubMed: 25915567 | |
dc.identifier.other | Scopus: 84930814496 | |
dc.identifier.other | PubMed: 25915567 | |
dc.identifier.other | ORCID: /0000-0002-8091-1458/work/27201536 | |
dc.identifier.other | WOS: 000360840000003 | |
dc.identifier.uri | https://hdl.handle.net/10023/6589 | |
dc.description.abstract | Context: Tumors producing insulin-like growth factor 2 (IGF-2oma) are a major cause of spontaneous hypoglycemia. The treatment mainstay is surgical resection. Many case reports note resolution of hypoglycemia after IGF-2oma resection; however, outcomes are variable according to tumor type. We report a case of resolving hypoglycemia, observed on continuous glucose monitoring (CGM), after resection of an IGF-2-producing solitary fibrous tumor, of pleura and review the current literature. Case Report: A 69-year-old woman presented with impaired consciousness because of hypoglycemia. An IGF-2oma was diagnosed as the cause for hypoglycemia because of decreased serum insulin and IGF-1, presence of a pleural tumor, and a high-molecular-weight form of serum IGF-2 detected by western immunoblot. Surgical resection was performed; pathological examination demonstrated a solitary fibrous tumor with low-grade malignancy. CGM showed reversal of hypoglycemia after tumor resection. Approximately 2 years after resection, the patient has no signs of tumor recurrence or hypoglycemia. Conclusions: An IGF-2-producing solitary fibrous tumor of pleura in this case caused hypoglycemia. From a search of the literature of 2004–2014, 32 cases of IGF-2oma with hypoglycemia that underwent radical surgery were identified; in 19 (59%) patients, hypoglycemia was reversed and there was no subsequent recurrence. The remaining 13 (41%) experienced tumor recurrence or metastasis and recurrence of hypoglycemia average 43 months after initial tumor resection. The tumor of the present case was a low-grade malignancy. Regular follow-up with biomarker-monitoring of glucose metabolism and assessment of hypoglycemic symptomatology, in conjunction with imaging tests, is important for detecting possible tumor recurrence and metastasis. | |
dc.format.extent | 7 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Clinical Endocrinology & Metabolism | en |
dc.rights | Copyright © 2015 by the Endocrine Society. | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Age Factors | en |
dc.subject | Aging | en |
dc.subject | Cell Size | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Infant, Newborn | en |
dc.subject | Menopause | en |
dc.subject | Middle Aged | en |
dc.subject | Ovarian Follicle | en |
dc.subject | Ovarian Reserve | en |
dc.subject | Ovary | en |
dc.subject | Pregnancy | en |
dc.subject | Young Adult | en |
dc.subject | Journal Article | en |
dc.subject | Research Support, Non-U.S. Gov't | en |
dc.subject | QA75 Electronic computers. Computer science | en |
dc.subject | R Medicine | en |
dc.subject | 3rd-DAS | en |
dc.subject.lcc | QA75 | en |
dc.subject.lcc | R | en |
dc.title | The relation between variation in size of the primordial follicle pool and age at natural menopause | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | EPSRC | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Computer Science | en |
dc.contributor.institution | University of St Andrews. Centre for Interdisciplinary Research in Computational Algebra | en |
dc.identifier.doi | https://doi.org/10.1210/jc.2015-1298 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | EP/H004092/1 | en |
dc.identifier.grantnumber | N/A | en |
dc.identifier.grantnumber | EP/K503940/1 | en |
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