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dc.contributor.authorDepmann, M
dc.contributor.authorFaddy, M J
dc.contributor.authorvan der Schoew, Y T
dc.contributor.authorPeeters, P H M
dc.contributor.authorBroer, S L
dc.contributor.authorKelsey, Tom
dc.contributor.authorNelson, S M
dc.contributor.authorBroekmans, F J M
dc.identifier.citationDepmann , M , Faddy , M J , van der Schoew , Y T , Peeters , P H M , Broer , S L , Kelsey , T , Nelson , S M & Broekmans , F J M 2015 , ' The relation between variation in size of the primordial follicle pool and age at natural menopause ' , Journal of Clinical Endocrinology & Metabolism , vol. 100 , no. 6 , pp. E852-E860 .
dc.identifier.otherPURE: 183861720
dc.identifier.otherPURE UUID: a2a8e0a5-3f90-425e-ae87-8c70199b6284
dc.identifier.otherPubMed: 25915567
dc.identifier.otherScopus: 84930814496
dc.identifier.otherPubMed: 25915567
dc.identifier.otherORCID: /0000-0002-8091-1458/work/27201536
dc.identifier.otherWOS: 000360840000003
dc.description.abstractContext: Tumors producing insulin-like growth factor 2 (IGF-2oma) are a major cause of spontaneous hypoglycemia. The treatment mainstay is surgical resection. Many case reports note resolution of hypoglycemia after IGF-2oma resection; however, outcomes are variable according to tumor type. We report a case of resolving hypoglycemia, observed on continuous glucose monitoring (CGM), after resection of an IGF-2-producing solitary fibrous tumor, of pleura and review the current literature. Case Report: A 69-year-old woman presented with impaired consciousness because of hypoglycemia. An IGF-2oma was diagnosed as the cause for hypoglycemia because of decreased serum insulin and IGF-1, presence of a pleural tumor, and a high-molecular-weight form of serum IGF-2 detected by western immunoblot. Surgical resection was performed; pathological examination demonstrated a solitary fibrous tumor with low-grade malignancy. CGM showed reversal of hypoglycemia after tumor resection. Approximately 2 years after resection, the patient has no signs of tumor recurrence or hypoglycemia. Conclusions: An IGF-2-producing solitary fibrous tumor of pleura in this case caused hypoglycemia. From a search of the literature of 2004–2014, 32 cases of IGF-2oma with hypoglycemia that underwent radical surgery were identified; in 19 (59%) patients, hypoglycemia was reversed and there was no subsequent recurrence. The remaining 13 (41%) experienced tumor recurrence or metastasis and recurrence of hypoglycemia average 43 months after initial tumor resection. The tumor of the present case was a low-grade malignancy. Regular follow-up with biomarker-monitoring of glucose metabolism and assessment of hypoglycemic symptomatology, in conjunction with imaging tests, is important for detecting possible tumor recurrence and metastasis.
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolismen
dc.rightsCopyright © 2015 by the Endocrine Society.en
dc.subjectAge Factorsen
dc.subjectCell Sizeen
dc.subjectChild, Preschoolen
dc.subjectInfant, Newbornen
dc.subjectMiddle Ageden
dc.subjectOvarian Follicleen
dc.subjectOvarian Reserveen
dc.subjectYoung Adulten
dc.subjectJournal Articleen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectQA75 Electronic computers. Computer scienceen
dc.subjectR Medicineen
dc.titleThe relation between variation in size of the primordial follicle pool and age at natural menopauseen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews.School of Computer Scienceen
dc.contributor.institutionUniversity of St Andrews.Centre for Interdisciplinary Research in Computational Algebraen
dc.description.statusPeer revieweden

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