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dc.contributor.advisorNolan, Steven P.
dc.contributor.authorGómez Suárez, Adrián
dc.coverage.spatial166en_US
dc.date.accessioned2015-04-23T12:51:56Z
dc.date.available2015-04-23T12:51:56Z
dc.date.issued2014-12-01
dc.identifieruk.bl.ethos.644825
dc.identifier.urihttp://hdl.handle.net/10023/6546
dc.description.abstractThe use of Au-NHC complexes in homogenous gold catalysis has become very popular during the last 10 years. The work described in this thesis represents a modest contribution towards a better understanding of the reactivity of these fascinating complexes and the intermediate species involved during gold-catalysed transformations. There are two main themes that permeate the following chapters: a) synthesis and reactivity studies of monoaurated species and b) synthesis and reactivity studies of diaurated species. The main motivation for the work presented herein was to develop more efficient synthetic routes towards a series of gold complexes, such as [Au(NHC)Cl], [Au(NHC)(OH)] and [{Au(IPr)}₂(μ-OH)][X], in order to be able to further explore their reactivity. Chapter 2 constitutes the first approach that I had with the chemistry of Au-NHC complexes, and describes our efforts to evaluate how the use of a highly sterically demanding NHC ligand affects gold-catalysed transformations. Chapters 3 and 4 explore alternative, more efficient synthetic routes towards known Au- NHC complexes. For example, a new, highly robust protocol has been developed for the synthesis of [Au(NHC)X] (X = Cl, Br, I) complexes, which are the starting materials to prepare a wide range of Au-NHC based species. Moreover, as a result of our investigations it has been possible to isolate a series of [Au(NHC)(OH)] species and to gain some insight into the stability of these complexes. Chapters 5 and 6 describe the synthesis and applications of digold hydroxide species [{Au(IPr)}₂(μ-OH)][X] in a series of catalytic and stoichiometric transformations. For example, they have been used as silver-free catalysts for water-inclusive gold-catalysed transformations or to access key intermediates in gold catalysis, such as gem-diaurated and σ,π-digold-acetylide species. Finally, Chapter 7 combines what we learned about the reactivity of [{Au(IPr)}₂(μ- OH)][X] in order to develop for the first time a gold-catalysed transformation where two gold centres independently react with two substrate molecules to catalyse the hydrophenoxylation of alkynes.en_US
dc.language.isoenen_US
dc.publisherUniversity of St Andrews
dc.subjectGolden_US
dc.subjectHomogeneous catalysisen_US
dc.subjectNHCen_US
dc.subjectMetal hydroxidesen_US
dc.subjectDual activationen_US
dc.subject.lccQD412.A9G7
dc.subject.lcshOrganogold compounds--Synthesisen_US
dc.subject.lcshOrganogold compounds--Analysisen_US
dc.subject.lcshHomogeneous catalysisen_US
dc.subject.lcshHeterocyclic compoundsen_US
dc.subject.lcshCarbenes (Methylene compounds)en_US
dc.subject.lcshLigandsen_US
dc.titleSynthesis and reactivity studies of mono- and diaurated species bearing N-heterocyclic carbene ligandsen_US
dc.typeThesisen_US
dc.type.qualificationlevelDoctoralen_US
dc.type.qualificationnamePhD Doctor of Philosophyen_US
dc.publisher.institutionThe University of St Andrewsen_US


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