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dc.contributor.authorWolf, Robert C
dc.contributor.authorSambataro, Fabio
dc.contributor.authorVasic, Nenad
dc.contributor.authorBaldas, Eva-Maria
dc.contributor.authorRatheiser, Iris
dc.contributor.authorLandwehrmeyer, G Bernhard
dc.contributor.authorDepping, Malte S
dc.contributor.authorThomann, Philipp A
dc.contributor.authorSprengelmeyer, Reiner Heinrich
dc.contributor.authorSüssmuth, Sigurd S
dc.contributor.authorOrth, Michael
dc.identifier.citationWolf , R C , Sambataro , F , Vasic , N , Baldas , E-M , Ratheiser , I , Landwehrmeyer , G B , Depping , M S , Thomann , P A , Sprengelmeyer , R H , Süssmuth , S S & Orth , M 2014 , ' Visual system integrity and cognition in early Huntington's disease ' , European Journal of Neuroscience , vol. 40 , no. 2 , pp. 2417–2426 .
dc.identifier.otherPURE: 108430729
dc.identifier.otherPURE UUID: 4544dc39-dc69-4d9d-afd9-af78c6c92860
dc.identifier.otherORCID: /0000-0002-3083-5995/work/64697282
dc.identifier.otherScopus: 84904598642
dc.identifier.otherWOS: 000339716300010
dc.description.abstractPosterior cortical volume changes and abnormal visuomotor performance are present in patients with Huntington's disease (HD). However, it is unclear whether posterior cortical volume loss contributes to abnormal neural activity, and whether activity changes predict cognitive dysfunction. Using magnetic resonance imaging (MRI), we investigated brain structure and visual network activity at rest in patients with early HD (n = 20) and healthy controls (n = 20). The symbol digit modalities test (SDMT) and subtests of the Visual Object and Space Perception Battery were completed offline. For functional MRI data, a group independent component analysis was used. Voxel-based morphometry was employed to assess regional brain atrophy, and ‘biological parametric mapping’ analyses were included to investigate the impact of atrophy on neural activity. Patients showed significantly worse visuomotor and visual object performance than controls. Structural analyses confirmed occipitotemporal atrophy. In patients and controls, two spatiotemporally distinct visual systems were identified. Patients showed decreased activity in the left fusiform cortex, and increased left cerebellar activity. These findings remained stable after correction for brain atrophy. Lower fusiform cortex activity was associated with lower SDMT performance and with higher disease burden scores. These associations were absent when cerebellar function was related to task performance and disease burden. The results of this study suggest that regionally specific functional abnormalities of the visual system can account for the worse visuomotor cognition in HD patients. However, occipital volume changes cannot sufficiently explain abnormal neural function in these patients.
dc.relation.ispartofEuropean Journal of Neuroscienceen
dc.rights© 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is the accepted version of the following article: Wolf, R. C., Sambataro, F., Vasic, N., Baldas, E.-M., Ratheiser, I., Bernhard Landwehrmeyer, G., Depping, M. S., Thomann, P. A., Sprengelmeyer, R., Süssmuth, S. D. and Orth, M. (2014), Visual system integrity and cognition in early Huntington's disease. European Journal of Neuroscience, 40: 2417–2426, which has been published in final form at
dc.subjectIndependent Component Analysisen
dc.subjectMagnetic Resonance Imagingen
dc.subjectOccipital Cortexen
dc.subjectResting Stateen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.titleVisual system integrity and cognition in early Huntington's diseaseen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Psychology and Neuroscienceen
dc.contributor.institutionUniversity of St Andrews. Institute of Behavioural and Neural Sciencesen
dc.description.statusPeer revieweden

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