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dc.contributor.authorWeber, H.
dc.contributor.authorKlamer, D.
dc.contributor.authorFreudenberg, F.
dc.contributor.authorKittel-Schneider, S.
dc.contributor.authorRivero, O.
dc.contributor.authorScholz, C. -J.
dc.contributor.authorVolkert, J.
dc.contributor.authorKopf, J.
dc.contributor.authorHeupel, J.
dc.contributor.authorHerterich, S.
dc.contributor.authorAdolfsson, R.
dc.contributor.authorAlttoa, A.
dc.contributor.authorPost, A.
dc.contributor.authorGrussendorf, H.
dc.contributor.authorKramer, A.
dc.contributor.authorGessner, A.
dc.contributor.authorSchmidt, B.
dc.contributor.authorHempel, S.
dc.contributor.authorJacob, C. P.
dc.contributor.authorSanjuan, J.
dc.contributor.authorMolto, M. D.
dc.contributor.authorLesch, K. -P.
dc.contributor.authorFreitag, C. M.
dc.contributor.authorKent, L.
dc.contributor.authorReif, A.
dc.date.accessioned2015-03-31T11:01:02Z
dc.date.available2015-03-31T11:01:02Z
dc.date.issued2014-01
dc.identifier.citationWeber , H , Klamer , D , Freudenberg , F , Kittel-Schneider , S , Rivero , O , Scholz , C -J , Volkert , J , Kopf , J , Heupel , J , Herterich , S , Adolfsson , R , Alttoa , A , Post , A , Grussendorf , H , Kramer , A , Gessner , A , Schmidt , B , Hempel , S , Jacob , C P , Sanjuan , J , Molto , M D , Lesch , K -P , Freitag , C M , Kent , L & Reif , A 2014 , ' The genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia : further evidence and meta-analysis ' , European Neuropsychopharmacology , vol. 24 , no. 1 , pp. 65-85 . https://doi.org/10.1016/j.euroneuro.2013.09.005en
dc.identifier.issn0924-977X
dc.identifier.otherPURE: 129080182
dc.identifier.otherPURE UUID: 59557b87-1a41-436f-b27d-2362dce4b840
dc.identifier.otherWOS: 000330816200004
dc.identifier.otherScopus: 84892477481
dc.identifier.otherORCID: /0000-0002-5315-3399/work/60195338
dc.identifier.otherWOS: 000330816200004
dc.identifier.urihttp://hdl.handle.net/10023/6401
dc.description.abstractNO is a pleiotropic signaling molecule and has an important role in cognition and emotion. In the brain, NO is produced by neuronal nitric oxide synthase (NOS-I, encoded by NOS1) coupled to the NMDA receptor via PDZ. interactions; this protein-protein interaction is disrupted upon binding of NOS1 adapter protein (encoded by NOS1AP) to NOS-I. As both NOS1 and NOS1AP were associated with schizophrenia, we here investigated these genes in greater detail by genotyping new samples and conducting a meta-analysis of our own and published data. In doing so, we confirmed association of both genes with schizophrenia and found evidence for their interaction in increasing risk towards disease. Our strongest finding was the NOS1 promoter SNP rs41279104, yielding an odds ratio of 1.29 in the meta-analysis. As findings from heterologous cell systems have suggested that the risk allele decreases gene expression, we studied the effect of the variant on NOS1 expression in human post-mortem brain samples and found that the risk allele significantly decreases expression of NOS1 in the prefrontal cortex. Bioinformatic analyses suggest that this might be due the replacement of six transcription factor binding sites by two new binding sites as a consequence of proxy SNPs. Taken together, our data argue that genetic variance in NOS1 resulting in lower prefrontal brain expression of this gene contributes to schizophrenia liability, and that NOS1 interacts with NOS1AP in doing so. The NOS1-NOS1AP PDZ interface may thus well constitute a novel target for small molecules in at least some forms of schizophrenia. 
dc.format.extent21
dc.language.isoeng
dc.relation.ispartofEuropean Neuropsychopharmacologyen
dc.rightsCopyright 2014 Elsevier B.V. and ECNP. All rights reserved. This is the author’s version of a work that was accepted for publication in European Neuropsychopharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Neuropsychopharmacology, 24, 1, January 2014 DOI 10.1016/j.euroneuro.2013.09.005en
dc.subjectGlutamateen
dc.subjectNitric oxideen
dc.subjectAssociationen
dc.subjectSchizophreniaen
dc.subjectPost-synapseen
dc.subjectPrefrontal cortexen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subject.lccRC0321en
dc.titleThe genetic contribution of the NO system at the glutamatergic post-synapse to schizophrenia : further evidence and meta-analysisen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Medicineen
dc.contributor.institutionUniversity of St Andrews.Institute of Behavioural and Neural Sciencesen
dc.identifier.doihttps://doi.org/10.1016/j.euroneuro.2013.09.005
dc.description.statusPeer revieweden


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