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dc.contributor.authorBrittenden, Julie
dc.contributor.authorCotton, Seonaidh C
dc.contributor.authorElders, Andrew
dc.contributor.authorRamsay, Craig R
dc.contributor.authorNorrie, John
dc.contributor.authorBurr, Jennifer
dc.contributor.authorCampbell, Bruce
dc.contributor.authorBachoo, Paul
dc.contributor.authorChetter, Ian
dc.contributor.authorGough, Michael
dc.contributor.authorEarnshaw, Jonothan
dc.contributor.authorLees, Tim
dc.contributor.authorScott, Julian
dc.contributor.authorBaker, Sara A
dc.contributor.authorFrancis, Jill
dc.contributor.authorTassie, Emma
dc.contributor.authorScotland, Graham
dc.contributor.authorWileman, Samantha
dc.contributor.authorCampbell, Marion K
dc.identifier.citationBrittenden , J , Cotton , S C , Elders , A , Ramsay , C R , Norrie , J , Burr , J , Campbell , B , Bachoo , P , Chetter , I , Gough , M , Earnshaw , J , Lees , T , Scott , J , Baker , S A , Francis , J , Tassie , E , Scotland , G , Wileman , S & Campbell , M K 2014 , ' A randomized trial comparing treatments for varicose veins ' , New England Journal of Medicine , vol. 371 , no. 13 , pp. 1218-1227 .
dc.identifier.otherPURE: 151404883
dc.identifier.otherPURE UUID: dcdbc371-d7a5-4eec-916c-f99c95b35332
dc.identifier.otherPubMed: 25251616
dc.identifier.otherWOS: 000342079700009
dc.identifier.otherScopus: 84907424144
dc.identifier.otherORCID: /0000-0002-9478-738X/work/60196183
dc.descriptionSupported by a grant from the Health Technology Assessment Programme of the National Institute for Health Research (06/45/02). The Health Services Research Unit is funded by the Chief Scientist Office of the Scottish Government Health Directorate.en
dc.description.abstractBackground Ultrasound-guided foam sclerotherapy and endovenous laser ablation are widely used alternatives to surgery for the treatment of varicose veins, but their comparative effectiveness and safety remain uncertain. Methods In a randomized trial involving 798 participants with primary varicose veins at 11 centers in the United Kingdom, we compared the outcomes of foam, laser, and surgical treatments. Primary outcomes at 6 months were disease-specific quality of life and generic quality of life, as measured on several scales. Secondary outcomes included complications and measures of clinical success. Results After adjustment for baseline scores and other covariates, the mean disease-specific quality of life was slightly worse after treatment with foam than after surgery (P=0.006) but was similar in the laser and surgery groups. There were no significant differences between the surgery group and the foam or the laser group in measures of generic quality of life. The frequency of procedural complications was similar in the foam group (6%) and the surgery group (7%) but was lower in the laser group (1%) than in the surgery group (P<0.001); the frequency of serious adverse events (approximately 3%) was similar among the groups. Measures of clinical success were similar among the groups, but successful ablation of the main trunks of the saphenous vein was less common in the foam group than in the surgery group (P<0.001). ConclusionsQuality-of-life measures were generally similar among the study groups, with the exception of a slightly worse disease-specific quality of life in the foam group than in the surgery group. All treatments had similar clinical efficacy, but complications were less frequent after laser treatment and ablation rates were lower after foam treatment.
dc.relation.ispartofNew England Journal of Medicineen
dc.rights© 2014. Massachusetts Medical Society. All rights reserved.en
dc.subjectRD Surgeryen
dc.subjectR Medicineen
dc.titleA randomized trial comparing treatments for varicose veinsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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