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Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations

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dc.contributor.authorBader, S
dc.contributor.authorWalker, M
dc.contributor.authorHarrison, D
dc.date.accessioned2015-03-16T12:31:03Z
dc.date.available2015-03-16T12:31:03Z
dc.date.issued2000
dc.identifier173402504
dc.identifier65f733b8-0a88-4ff1-a7c8-dbfd8fb53da5
dc.identifier0034543135
dc.identifier.citationBader , S , Walker , M & Harrison , D 2000 , ' Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations ' , British Journal of Cancer , vol. 83 , no. 12 , pp. 1646-1649 . https://doi.org/10.1054/bjoc.2000.1482en
dc.identifier.issn0007-0920
dc.identifier.otherRIS: urn:19D77FF3FA1DE366B31BB25EFBD6A207
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034288
dc.identifier.urihttps://hdl.handle.net/10023/6246
dc.description.abstractThe MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.
dc.format.extent4
dc.format.extent61695
dc.language.isoeng
dc.relation.ispartofBritish Journal of Canceren
dc.subjectMBD4en
dc.subjectColorectal canceren
dc.subjectMicrosatellite instabilityen
dc.subjectR Medicine (General)en
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subject.lccR1en
dc.subject.lccRC0254en
dc.titleMost microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutationsen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.identifier.doi10.1054/bjoc.2000.1482
dc.description.statusPeer revieweden
dc.identifier.urlhttp://www.nature.com/bjc/journal/v83/n12/full/6691482a.htmlen


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