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dc.contributor.authorWheelhouse, N M
dc.contributor.authorLai, P B S
dc.contributor.authorWigmore, S J
dc.contributor.authorRoss, J A
dc.contributor.authorHarrison, D J
dc.identifier.citationWheelhouse , N M , Lai , P B S , Wigmore , S J , Ross , J A & Harrison , D J 2005 , ' Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver ' , British Journal of Cancer , vol. 92 , no. 7 , pp. 1268-1272 .
dc.identifier.otherRIS: urn:C5F7F898ABA31582AD7841CF2B4DF94D
dc.identifier.otherORCID: /0000-0001-9041-9988/work/64034185
dc.description.abstractThe largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was carried out to determine whether mitochondrial DNA abnormalities were associated with HCC in individuals with HBV. The frequency of mutation and deletion of specific areas of the mitochondrial genome in tumour and matched normal tissue of patients with HBV infection was investigated in the current study. The percentage of control subjects harbouring D-loop mutations was 11%, which was significantly lower than that observed in both the noncancerous (49%, P=0.033) and tumour tissue (59%, P=0.014) of patients with HCC. In contrast, the number of cases in which the common 4977?bp deletion of the mitochondrial genome was detected was significantly greater in control liver and noncancerous liver tissue of subjects with HCC (100 and 95%, respectively) than in cancerous liver tissue (28%, P<0.001). These observations suggest that the inflammatory process contributes to the rate of mitochondrial mutations. However, the lower frequency of the large deletion in cancerous tissue suggests that there is selection against either mitochondria, which harbour large deletions, or against cells that contain these mitochondria during hepatocarcinogenesis.
dc.relation.ispartofBritish Journal of Canceren
dc.subjectMitochondrial DNAen
dc.subjectViral hepatitisen
dc.subjectR Medicineen
dc.subjectRC0254 Neoplasms. Tumors. Oncology (including Cancer)en
dc.subjectSDG 3 - Good Health and Well-beingen
dc.titleMitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liveren
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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