Files in this item
On the chemical biology of the nitrite/sulfide interaction
Item metadata
dc.contributor.author | Cortese-Krott, M.M. | |
dc.contributor.author | Fernandez, B.O. | |
dc.contributor.author | Kelm, M. | |
dc.contributor.author | Butler, A.R. | |
dc.contributor.author | Feelisch, M. | |
dc.date.accessioned | 2015-02-17T15:01:03Z | |
dc.date.available | 2015-02-17T15:01:03Z | |
dc.date.issued | 2015-04-30 | |
dc.identifier.citation | Cortese-Krott , M M , Fernandez , B O , Kelm , M , Butler , A R & Feelisch , M 2015 , ' On the chemical biology of the nitrite/sulfide interaction ' , Nitric Oxide , vol. 46 , pp. 14-24 . https://doi.org/10.1016/j.niox.2014.12.009 | en |
dc.identifier.issn | 1089-8603 | |
dc.identifier.other | PURE: 164179636 | |
dc.identifier.other | PURE UUID: 21a2428a-cd8e-481a-88cf-6f882a90ae2b | |
dc.identifier.other | WOS: 000351483700003 | |
dc.identifier.other | Scopus: 84925499113 | |
dc.identifier.uri | https://hdl.handle.net/10023/6116 | |
dc.description | The authors are grateful to the Susanne-Bunnenberg-Stiftung of the Düsseldorf Heart Center (to MK), the COST action BM1005 (European Network on Gasotransmitters), and the Faculty of Medicine, University of Southampton (to MF) for financial support. | en |
dc.description.abstract | Sulfide (H2S/HS−) has been demonstrated to exert an astounding breadth of biological effects, some of which resemble those of nitric oxide (NO). While the chemistry, biochemistry and potential pathophysiology of the cross-talk between sulfide and NO have received considerable attention lately, a comparable assessment of the potential biological implications of an interaction between nitrite and sulfide is lacking. This is surprising inasmuch as nitrite is not only a known bioactive oxidation product of NO, but also efficiently converted to S-nitrosothiols in vivo; the latter have been shown to rapidly react with sulfide in vitro, leading to formation of S/N-hybrid species including thionitrite (SNO−) and nitrosopersulfide (SSNO−). Moreover, nitrite is used as a potent remedy against sulfide poisoning in the clinic. The chemistry of interaction between nitrite and sulfide or related bioactive metabolites including polysulfides and elemental sulfur has been extensively studied in the past, yet much of this information appears to have been forgotten. In this review, we focus on the potential chemical biology of the interaction between nitrite and sulfide or sulfane sulfur molecules, calling attention to the fundamental chemical properties and reactivities of either species and discuss their possible contribution to the biology, pharmacology and toxicology of both nitrite and sulfide. | |
dc.language.iso | eng | |
dc.relation.ispartof | Nitric Oxide | en |
dc.rights | Copyright the Authors 2014. This article is covered by the Creative Commons Attribution license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | en |
dc.subject | Sulfide | en |
dc.subject | Nitrite | en |
dc.subject | Nitroxyl | en |
dc.subject | SSNO− | en |
dc.subject | Sulfane sulfur | en |
dc.subject | Hypoxia | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject.lcc | QD | en |
dc.title | On the chemical biology of the nitrite/sulfide interaction | en |
dc.type | Journal article | en |
dc.description.version | Publisher PDF | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | https://doi.org/10.1016/j.niox.2014.12.009 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1089860314005163#appd002 | en |
This item appears in the following Collection(s)
Items in the St Andrews Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.