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Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange
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dc.contributor.author | della Sala, Flavio | |
dc.contributor.author | Kay, Euan Robert | |
dc.date.accessioned | 2015-02-10T09:31:02Z | |
dc.date.available | 2015-02-10T09:31:02Z | |
dc.date.issued | 2015-03-27 | |
dc.identifier | 167111236 | |
dc.identifier | 761b9665-0b08-4bae-8963-33d33f4e252c | |
dc.identifier | 84925459654 | |
dc.identifier | 000351679600004 | |
dc.identifier.citation | della Sala , F & Kay , E R 2015 , ' Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange ' , Angewandte Chemie International Edition , vol. 54 , no. 14 , pp. 4187–4191 . https://doi.org/10.1002/anie.201409602 | en |
dc.identifier.issn | 1433-7851 | |
dc.identifier.other | ORCID: /0000-0001-8177-6393/work/56862255 | |
dc.identifier.uri | https://hdl.handle.net/10023/6080 | |
dc.description | This work was supported by the EPSRC (EP/K016342/1 and DTG), the University of St Andrews, and by a Royal Society of Edinburgh/Scottish Government Fellowship (E.R.K.). | en |
dc.description.abstract | Existing methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide-based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle-bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface-bound species, and real-time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching—and subtly tuning—NP properties such as solvophilicity. | |
dc.format.extent | 1256433 | |
dc.language.iso | eng | |
dc.relation.ispartof | Angewandte Chemie International Edition | en |
dc.subject | Dynamic covalent chemistry | en |
dc.subject | Gold nanoparticles | en |
dc.subject | Hydrazones | en |
dc.subject | Supramolecular chemistry | en |
dc.subject | QD Chemistry | en |
dc.subject | NDAS | en |
dc.subject | BDC | en |
dc.subject | R2C | en |
dc.subject.lcc | QD | en |
dc.title | Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | The Royal Society of Edinburgh | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.identifier.doi | https://doi.org/10.1002/anie.201409602 | |
dc.description.status | Peer reviewed | en |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/anie.201409602/suppinfo | en |
dc.identifier.grantnumber | EP/K016342/1 | en |
dc.identifier.grantnumber | n/a | en |
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