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dc.contributor.authordella Sala, Flavio
dc.contributor.authorKay, Euan Robert
dc.date.accessioned2015-02-10T09:31:02Z
dc.date.available2015-02-10T09:31:02Z
dc.date.issued2015-03-27
dc.identifier.citationdella Sala , F & Kay , E R 2015 , ' Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange ' , Angewandte Chemie International Edition , vol. 54 , no. 14 , pp. 4187–4191 . https://doi.org/10.1002/anie.201409602en
dc.identifier.issn1433-7851
dc.identifier.otherPURE: 167111236
dc.identifier.otherPURE UUID: 761b9665-0b08-4bae-8963-33d33f4e252c
dc.identifier.otherScopus: 84925459654
dc.identifier.otherORCID: /0000-0001-8177-6393/work/56862255
dc.identifier.otherWOS: 000351679600004
dc.identifier.urihttp://hdl.handle.net/10023/6080
dc.descriptionThis work was supported by the EPSRC (EP/K016342/1 and DTG), the University of St Andrews, and by a Royal Society of Edinburgh/Scottish Government Fellowship (E.R.K.).en
dc.description.abstractExisting methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide-based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle-bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface-bound species, and real-time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching—and subtly tuning—NP properties such as solvophilicity.
dc.language.isoeng
dc.relation.ispartofAngewandte Chemie International Editionen
dc.rights© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.subjectDynamic covalent chemistryen
dc.subjectGold nanoparticlesen
dc.subjectHydrazonesen
dc.subjectSupramolecular chemistryen
dc.subjectQD Chemistryen
dc.subjectNDASen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccQDen
dc.titleReversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchangeen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Chemistryen
dc.contributor.institutionUniversity of St Andrews.EaSTCHEMen
dc.identifier.doihttps://doi.org/10.1002/anie.201409602
dc.description.statusPeer revieweden
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201409602/suppinfoen


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