Porous, rigid metal(III)-carboxylate metal-organic frameworks for the delivery of nitric oxide
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The room temperature sorption properties of the biological gas nitric oxide (NO) have been investigated on the highly porous and rigid iron or chromium carboxylate based metal-organic frameworks Material Institut Lavoisier (MIL)-100(Fe or Cr) and MIL-127(Fe). In all cases, a significant amount of NO is chemisorbed at 298 K with a loading capacity that depends both on the nature of the metal cation, the structure and the presence of additional iron(II) Lewis acid sites. In a second step, the release of NO triggered by wet nitrogen gas has been studied by chemiluminescence and indicates that only a partial release of NO occurs as well as a prolonged delivery at the biological level. Finally, an in situ infrared spectroscopy study confirms not only the coordination of NO over the Lewis acid sites and the stronger binding of NO on the additional iron(II) sites, providing further insights over the partial release of NO only in the presence of water at room temperature.
Eubank , J F , Wheatley , P S , Lebars , G , McKinlay , A C , Leclerc , H , Horcajada , P , Daturi , M , Vimont , A , Morris , R E & Serre , C 2014 , ' Porous, rigid metal(III)-carboxylate metal-organic frameworks for the delivery of nitric oxide ' APL Materials , vol 2 , no. 12 , 124112 . DOI: 10.1063/1.4904069
© 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License.
This work was supported by CNRS, EU through the ERC-2007-209241-BioMOFs ERC grant (J.F.E., P.H., C.S.). R.E.M. thanks the GEMI Fund and the E.P.S.R.C for funding. R.E.M is a Royal Society Wolfson Merit Award Holder.
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