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dc.contributor.authorVan Bressem, M.-F.
dc.contributor.authorDuignan, P.J.
dc.contributor.authorBanyard, A.
dc.contributor.authorBarbieri, M.
dc.contributor.authorColegrove, K.M.
dc.contributor.authorde Guise, S.
dc.contributor.authordi Guardo, G.
dc.contributor.authorDobson, A.
dc.contributor.authorDomingo, M.
dc.contributor.authorFauquier, D.
dc.contributor.authorFernandez, A.
dc.contributor.authorGoldstein, T.
dc.contributor.authorGrenfell, B.
dc.contributor.authorGroch, K.R.
dc.contributor.authorGulland, F.
dc.contributor.authorJensen, B.A.
dc.contributor.authorJepson, P.D.
dc.contributor.authorHall, A.
dc.contributor.authorKuiken, T.
dc.contributor.authorMazzariol, S.
dc.contributor.authorMorris, S.E.
dc.contributor.authorNielsen, O.
dc.contributor.authorRaga, J.A.
dc.contributor.authorRowles, T.K.
dc.contributor.authorSaliki, J.
dc.contributor.authorSierra, E.
dc.contributor.authorStephens, N.
dc.contributor.authorStone, B.
dc.contributor.authorTomo, I.
dc.contributor.authorWang, J.
dc.contributor.authorWaltzek, T.
dc.contributor.authorWellehan, J.F.X.
dc.date.accessioned2015-01-14T15:31:05Z
dc.date.available2015-01-14T15:31:05Z
dc.date.issued2014-12-22
dc.identifier.citationVan Bressem , M-F , Duignan , P J , Banyard , A , Barbieri , M , Colegrove , K M , de Guise , S , di Guardo , G , Dobson , A , Domingo , M , Fauquier , D , Fernandez , A , Goldstein , T , Grenfell , B , Groch , K R , Gulland , F , Jensen , B A , Jepson , P D , Hall , A , Kuiken , T , Mazzariol , S , Morris , S E , Nielsen , O , Raga , J A , Rowles , T K , Saliki , J , Sierra , E , Stephens , N , Stone , B , Tomo , I , Wang , J , Waltzek , T & Wellehan , J F X 2014 , ' Cetacean morbillivirus : current knowledge and future directions ' , Viruses , vol. 6 , no. 12 , pp. 5145-5181 . https://doi.org/10.3390/v6125145en
dc.identifier.issn1999-4915
dc.identifier.otherPURE: 161868014
dc.identifier.otherPURE UUID: 7697a434-1429-4293-9f9c-701be7014cec
dc.identifier.otherScopus: 84919820072
dc.identifier.otherWOS: 000346834500017
dc.identifier.otherORCID: /0000-0002-7562-1771/work/47136299
dc.identifier.urihttp://hdl.handle.net/10023/5996
dc.description.abstractWe review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USAand Australia. It represents a distinct species within the Morbillivirusgenus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus), from Western Australia, and a Guiana dolphin (Sotalia guianensis), from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM) cell receptor for CeMV has been characterized in cetaceans. It shares higher amino acid identity with the ruminant SLAM than with the receptors of carnivores or humans, reflecting the evolutionary history of these mammalian taxa. In Delphinidae, three amino acid substitutions may result in a higher affinity for the virus. Infection is diagnosed by histology, immunohistochemistry, virus isolation, RT-PCR, and serology. Classical CeMV-associated lesions include bronchointerstitial pneumonia, encephalitis, syncytia, and lymphoid depletion associated with immunosuppression. Cetaceans that survive the acute disease may develop fatal secondary infections and chronic encephalitis. Endemicallyinfected, gregarious odontocetes probably serve as reservoirs and vectors. Transmission likely occurs through the inhalation of aerosolized virus but mother to fetus transmission was also reported.
dc.format.extent37
dc.language.isoeng
dc.relation.ispartofVirusesen
dc.rights© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectCetacean morbillivirusen
dc.subjectEpidemicsen
dc.subjectMass strandingen
dc.subjectSLAMen
dc.subjectPhylogenyen
dc.subjectPathogenesisen
dc.subjectDiagnosisen
dc.subjectEndemic infectionsen
dc.subjectQH301 Biologyen
dc.subjectQR355 Virologyen
dc.subject.lccQH301en
dc.subject.lccQR355en
dc.titleCetacean morbillivirus : current knowledge and future directionsen
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Sea Mammal Research Uniten
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.identifier.doihttps://doi.org/10.3390/v6125145
dc.description.statusPeer revieweden


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