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dc.contributor.authorFlorence, Gordon John
dc.contributor.authorWang, Zhigang
dc.contributor.authorTai, Lik Ren
dc.contributor.authorMcLean, Donald
dc.contributor.authorWright, Emma Joanne
dc.contributor.authorBrown, Stuart I.
dc.contributor.authorAndré, Pascal
dc.contributor.authorCuschieri, Alfred
dc.identifier.citationFlorence , G J , Wang , Z , Tai , L R , McLean , D , Wright , E J , Brown , S I , André , P & Cuschieri , A 2014 , ' Mucoadhesive polymer films for tissue retraction in laparoscopic surgery : ex-vivo study on their mechanical properties ' , Bio-Medical Materials and Engineering , vol. 24 , no. 1 , pp. 445-451 .
dc.identifier.otherPURE: 84567605
dc.identifier.otherPURE UUID: de27981f-977c-4074-bf03-6b7c4f247d46
dc.identifier.otherScopus: 84891050820
dc.identifier.otherORCID: /0000-0001-9921-4399/work/56638885
dc.identifier.otherWOS: 000327312600052
dc.descriptionThis work was financially supported by the Engineering and Physical Sciences Research Council (EPSRC), UK, under Grant EP/H010033/1 and the Royal Society (GJF).en
dc.description.abstractSafe and effective manipulation of soft tissue during laparoscopic procedures can be achieved by the use of mucoadhesive polymer films. A series of novel adhesive polymer films were formulated in house based on either Carbopol or Chitosan modified systems. The mechanical properties of the polymers and their adherence to bowel were evaluated using ex-vivo pig bowel immersed in 37°C water bath and connected to an Instron tensiometer. Young's modulus was 300 kPa for the Carbopol-polymer and 5 kPa for the Chitosan-polymer. The Chitosan-polymer exhibited much larger shear adhesion than its tensile adhesion: 3.4 N vs. 1.2. Both tensile and shear adhesions contributed to the large retraction force (2.6 N) obtained during l polymer-bowel retraction testing. Work of adhesion at the polymer/serosa interface, defined as the area under the force curve, was 64 mJ, which is appreciably larger than that reported with existing polymers. In conclusion, adhesive polymers can stick to the serosal side of the bowel with an adhesive force, which is sufficient to lift the bowel, providing a lower retraction stress than that caused by laparoscopic grasping which induces high localized pressures on the tissue.
dc.relation.ispartofBio-Medical Materials and Engineeringen
dc.rightsCopyright © 2014 IOS Press. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at
dc.subjectMucoadhesive polymeren
dc.subjectMechanical propertyen
dc.subjectAdhesive forceen
dc.subjectLaparoscopic surgeryen
dc.subjectBowel retractionen
dc.subjectQD Chemistryen
dc.subjectBiomedical Engineeringen
dc.titleMucoadhesive polymer films for tissue retraction in laparoscopic surgery : ex-vivo study on their mechanical propertiesen
dc.typeJournal articleen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.contributor.institutionUniversity of St Andrews. School of Physics and Astronomyen
dc.contributor.institutionUniversity of St Andrews. School of Medicineen
dc.description.statusPeer revieweden

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