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Mucoadhesive polymer films for tissue retraction in laparoscopic surgery : ex-vivo study on their mechanical properties
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dc.contributor.author | Florence, Gordon John | |
dc.contributor.author | Wang, Zhigang | |
dc.contributor.author | Tai, Lik Ren | |
dc.contributor.author | McLean, Donald | |
dc.contributor.author | Wright, Emma Joanne | |
dc.contributor.author | Brown, Stuart I. | |
dc.contributor.author | André, Pascal | |
dc.contributor.author | Cuschieri, Alfred | |
dc.date.accessioned | 2014-12-11T13:01:02Z | |
dc.date.available | 2014-12-11T13:01:02Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Florence , G J , Wang , Z , Tai , L R , McLean , D , Wright , E J , Brown , S I , André , P & Cuschieri , A 2014 , ' Mucoadhesive polymer films for tissue retraction in laparoscopic surgery : ex-vivo study on their mechanical properties ' , Bio-Medical Materials and Engineering , vol. 24 , no. 1 , pp. 445-451 . https://doi.org/10.3233/BME-130829 | en |
dc.identifier.issn | 0959-2989 | |
dc.identifier.other | PURE: 84567605 | |
dc.identifier.other | PURE UUID: de27981f-977c-4074-bf03-6b7c4f247d46 | |
dc.identifier.other | Scopus: 84891050820 | |
dc.identifier.other | ORCID: /0000-0001-9921-4399/work/56638885 | |
dc.identifier.other | WOS: 000327312600052 | |
dc.identifier.uri | https://hdl.handle.net/10023/5915 | |
dc.description | This work was financially supported by the Engineering and Physical Sciences Research Council (EPSRC), UK, under Grant EP/H010033/1 and the Royal Society (GJF). | en |
dc.description.abstract | Safe and effective manipulation of soft tissue during laparoscopic procedures can be achieved by the use of mucoadhesive polymer films. A series of novel adhesive polymer films were formulated in house based on either Carbopol or Chitosan modified systems. The mechanical properties of the polymers and their adherence to bowel were evaluated using ex-vivo pig bowel immersed in 37°C water bath and connected to an Instron tensiometer. Young's modulus was 300 kPa for the Carbopol-polymer and 5 kPa for the Chitosan-polymer. The Chitosan-polymer exhibited much larger shear adhesion than its tensile adhesion: 3.4 N vs. 1.2. Both tensile and shear adhesions contributed to the large retraction force (2.6 N) obtained during l polymer-bowel retraction testing. Work of adhesion at the polymer/serosa interface, defined as the area under the force curve, was 64 mJ, which is appreciably larger than that reported with existing polymers. In conclusion, adhesive polymers can stick to the serosal side of the bowel with an adhesive force, which is sufficient to lift the bowel, providing a lower retraction stress than that caused by laparoscopic grasping which induces high localized pressures on the tissue. | |
dc.format.extent | 7 | |
dc.language.iso | eng | |
dc.relation.ispartof | Bio-Medical Materials and Engineering | en |
dc.rights | Copyright © 2014 IOS Press. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at http://dx.doi.org/10.3233/BME-130829 | en |
dc.subject | Mucoadhesive polymer | en |
dc.subject | Mechanical property | en |
dc.subject | Adhesive force | en |
dc.subject | Laparoscopic surgery | en |
dc.subject | Bowel retraction | en |
dc.subject | QD Chemistry | en |
dc.subject | Biomaterials | en |
dc.subject | Biomedical Engineering | en |
dc.subject.lcc | QD | en |
dc.title | Mucoadhesive polymer films for tissue retraction in laparoscopic surgery : ex-vivo study on their mechanical properties | en |
dc.type | Journal article | en |
dc.contributor.sponsor | EPSRC | en |
dc.contributor.sponsor | EPSRC | en |
dc.description.version | Postprint | en |
dc.contributor.institution | University of St Andrews. School of Chemistry | en |
dc.contributor.institution | University of St Andrews. Biomedical Sciences Research Complex | en |
dc.contributor.institution | University of St Andrews. EaSTCHEM | en |
dc.contributor.institution | University of St Andrews. School of Physics and Astronomy | en |
dc.contributor.institution | University of St Andrews. School of Medicine | en |
dc.identifier.doi | https://doi.org/10.3233/BME-130829 | |
dc.description.status | Peer reviewed | en |
dc.identifier.grantnumber | EP/H010033/1 | en |
dc.identifier.grantnumber | EP/H010033/1 | en |
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