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dc.contributor.authorMann, Greg
dc.contributor.authorKoehnke, Jesko Alexander Johannes Gunter
dc.contributor.authorBent, Andrew Frank
dc.contributor.authorGraham, Rachael
dc.contributor.authorHoussen, Wael
dc.contributor.authorJaspars, Marcel
dc.contributor.authorSchwarz-Linek, Uli
dc.contributor.authorNaismith, Jim
dc.identifier.citationMann , G , Koehnke , J A J G , Bent , A F , Graham , R , Houssen , W , Jaspars , M , Schwarz-Linek , U & Naismith , J 2014 , ' The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster ' , Acta Crystallographica. Section F, Structural biology and crystallization communications , vol. F70 , pp. 1597-1603 .
dc.identifier.otherPURE: 158745844
dc.identifier.otherPURE UUID: 0fa80343-3c3f-4777-80c4-2894c189b070
dc.identifier.otherScopus: 84927559406
dc.identifier.otherORCID: /0000-0003-0526-223X/work/40714968
dc.identifier.otherWOS: 000345843300005
dc.descriptionThis work was funded by the BBSRC (BB/K015508/1) and ERC (TNT-LEAP), and the University of St Andrews infrastructure is supported by a Wellcome Trust Capital Award (086036). WH is the recipient of the SULSA Leaders award.en
dc.description.abstractPatellamides are members of the cyanobactin family of ribosomally synthesized and post-translationally modified cyclic peptide natural products, many of which, including some patellamides, are biologically active. A detailed mechanistic understanding of the biosynthetic pathway would enable the construction of a biotechnological `toolkit' to make novel analogues of patellamides that are not found in nature. All but two of the protein domains involved in patellamide biosynthesis have been characterized. The two domains of unknown function (DUFs) are homologous to each other and are found at the C-termini of the multi-domain proteins PatA and PatG. The domain sequence is found in all cyanobactin-biosynthetic pathways characterized to date, implying a functional role in cyanobactin biosynthesis. Here, the crystal structure of the PatG DUF domain is reported and its binding interactions with plausible substrates are investigated.
dc.relation.ispartofActa Crystallographica. Section F, Structural biology and crystallization communicationsen
dc.rights©2014. The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.en
dc.subjectQD Chemistryen
dc.titleThe structure of the cyanobactin domain of unknown function from PatG in the patellamide gene clusteren
dc.typeJournal articleen
dc.description.versionPublisher PDFen
dc.contributor.institutionUniversity of St Andrews. School of Chemistryen
dc.contributor.institutionUniversity of St Andrews. School of Biologyen
dc.contributor.institutionUniversity of St Andrews. Biomedical Sciences Research Complexen
dc.contributor.institutionUniversity of St Andrews. EaSTCHEMen
dc.description.statusPeer revieweden

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