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dc.contributor.authorFoll, Matthieu
dc.contributor.authorGaggiotti, Oscar E
dc.contributor.authorDaub, Josephine T
dc.contributor.authorVatsiou, Alexandra
dc.contributor.authorExcoffier, Laurent
dc.date.accessioned2014-11-24T15:31:09Z
dc.date.available2014-11-24T15:31:09Z
dc.date.issued2014-10-02
dc.identifier.citationFoll , M , Gaggiotti , O E , Daub , J T , Vatsiou , A & Excoffier , L 2014 , ' Widespread signals of convergent adaptation to high altitude in Asia and America ' , American Journal of Human Genetics , vol. 95 , no. 4 , pp. 394-407 . https://doi.org/10.1016/j.ajhg.2014.09.002en
dc.identifier.issn0002-9297
dc.identifier.otherPURE: 154869403
dc.identifier.otherPURE UUID: 2835bbc4-1417-42ac-b215-100b9689b2c8
dc.identifier.otherPubMed: 25262650
dc.identifier.otherScopus: 84921786534
dc.identifier.otherWOS: 000342654300005
dc.identifier.otherORCID: /0000-0003-1827-1493/work/61370085
dc.identifier.urihttp://hdl.handle.net/10023/5833
dc.descriptionThis work has been made possible by Swiss National Science Foundation grants No. 3100A0-126074, 31003A-143393, and CRSII3_141940 to L.E. O.E.G. was supported by French ANR grant No 09-GENM-017-001 and by the Marine Alliance for Science and Technology for Scotland (MASTS).en
dc.description.abstractLiving at high altitude is one of the most difficult challenges that humans had to cope with during their evolution. Whereas several genomic studies have revealed some of the genetic bases of adaptations in Tibetan, Andean, and Ethiopian populations, relatively little evidence of convergent evolution to altitude in different continents has accumulated. This lack of evidence can be due to truly different evolutionary responses, but it can also be due to the low power of former studies that have mainly focused on populations from a single geographical region or performed separate analyses on multiple pairs of populations to avoid problems linked to shared histories between some populations. We introduce here a hierarchical Bayesian method to detect local adaptation that can deal with complex demographic histories. Our method can identify selection occurring at different scales, as well as convergent adaptation in different regions. We apply our approach to the analysis of a large SNP data set from low- and high-altitude human populations from America and Asia. The simultaneous analysis of these two geographic areas allows us to identify several candidate genome regions for altitudinal selection, and we show that convergent evolution among continents has been quite common. In addition to identifying several genes and biological processes involved in high-altitude adaptation, we identify two specific biological pathways that could have evolved in both continents to counter toxic effects induced by hypoxia.
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Human Geneticsen
dc.rights© 2014. The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved. This is the author’s version of a work that was accepted for publication in American Journal of Human Genetics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in American Journal of Human Genetics, 95, October 2014 DOI http://dx.doi.org/10.1016/j.ajhg.2014.09.002en
dc.subjectQH301 Biologyen
dc.subjectBDCen
dc.subjectR2Cen
dc.subject.lccQH301en
dc.titleWidespread signals of convergent adaptation to high altitude in Asia and Americaen
dc.typeJournal articleen
dc.description.versionPostprinten
dc.contributor.institutionUniversity of St Andrews.School of Biologyen
dc.contributor.institutionUniversity of St Andrews.Marine Alliance for Science & Technology Scotlanden
dc.contributor.institutionUniversity of St Andrews.Scottish Oceans Instituteen
dc.identifier.doihttps://doi.org/10.1016/j.ajhg.2014.09.002
dc.description.statusPeer revieweden


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